Antihypertensive Effect of Peptides Obtained from Enterococcus faecalis-Fermented Milk in Rats

Decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) caused in spontaneously hypertensive rats by the administration of water (○), captopril (□; 50mg/kg; Sigma, St. Louis, MO), or 4 different doses of the peptide sequence LHLPLP: 0.5 (♦), 1 (▴), 2 (■), and 3mg/kg (●). The data represent the mean values±SEM for a minimum of 6 rats. ^aP<0.05 vs. water; ^bP<0.05 vs. captopril; ^cP<0.05 vs. 0.5mg/kg of LHLPLP; ^dP<0.05 vs. 1mg/kg of LHLPLP. P estimated by a 2-way ANOVA.

Decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) caused in spontaneously hypertensive rats by the administration of water (○), captopril (□; 50mg/kg; Sigma, St. Louis, MO), or 2 different doses of the peptide sequence LVYPFPGPIPNSLP-QNIPP: 3 (♦) and 6mg/kg (▴). The data represent the mean values±SEM for a minimum of 6 rats. ^aP<0.05 vs. water; ^bP<0.05 vs. captopril; ^cP<0.05 vs. 3mg/kg of LVYPFPGPIPNSLPQNIPP. P estimated by a 2-way ANOVA.

Decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) caused in spontaneously hypertensive rats by the administration of different products: water (○), captopril (□; 50mg/kg; Sigma, St. Louis, MO), the peptide sequence LHLPLPL (♦; 10mg/kg), the peptide sequence VLGPVRGPFP (▴; 10mg/kg), or the peptide sequence VRGPFPIIV (■; 10mg/kg). The data represent the mean values±SEM for a minimum of 6 rats. ^aP<0.05 vs. water; ^bP<0.05 vs. captopril. P estimated by a 2-way ANOVA.