Journal of Dairy Science
Volume 90, Issue 6 , Pages 2624-2629 , June 2007

Milk and Urine Excretion of Polycyclic Aromatic Hydrocarbons and Their Hydroxylated Metabolites After a Single Oral Administration in Ruminants

  • D. Lapole

      Affiliations

    • UR AFPA, INPL-UHP-INRA, 2 avenue de la forêt de Haye, BP 172, 54505 Vandoeuvre-lès-Nancy, France
    • ,
  • G. Rychen

      Affiliations

    • UR AFPA, INPL-UHP-INRA, 2 avenue de la forêt de Haye, BP 172, 54505 Vandoeuvre-lès-Nancy, France
    • Corresponding Author InformationCorresponding author.
    • ,
  • N. Grova

      Affiliations

    • UR AFPA, INPL-UHP-INRA, 2 avenue de la forêt de Haye, BP 172, 54505 Vandoeuvre-lès-Nancy, France
    • ,
  • F. Monteau

      Affiliations

    • LABERCA, ENV Nantes, Rte de Gachet, BP 50707, 44307 Nantes cx 3, France
    • ,
  • B. Le Bizec

      Affiliations

    • LABERCA, ENV Nantes, Rte de Gachet, BP 50707, 44307 Nantes cx 3, France
    • ,
  • C. Feidt

      Affiliations

    • UR AFPA, INPL-UHP-INRA, 2 avenue de la forêt de Haye, BP 172, 54505 Vandoeuvre-lès-Nancy, France

Received 1 December 2006 ,Accepted 23 January 2007.

References 

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  2. Bouchard M, Viau C. Urinary and biliary excretion kinetics of 1-hydroxypyrene following intravenous and oral administration of pyrene in rats. Toxicology. 1998;127:69–84
  3. Buesen R, Mock M, Nau H, Seidel A, Jacob J, Lampen A. Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites. Chem. Biol. Interact. 2003;142:201–221
  4. Buesen R, Mock M, Seidel A, Jacob J, Lampen A. Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes. Toxicol. Appl. Pharmacol. 2002;183:168–178
  5. Cavret S, Feidt C. Intestinal metabolism of PAH: In vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium. Environ. Res. 2005;98:22–32
  6. Crepineau C, Rychen G, Feidt C, Le Roux Y, Lichtfouse E, Laurent F. Contamination of pastures by polycyclic aromatic hydrocarbons (PAHs) in the vicinity of a highway. J. Agric. Food Chem. 2003;51:4841–4845
  7. Grova N, Feidt C, Crepineau C, Laurent C, Lafargue PE, Hachimi A, et al. Detection of polycyclic aromatic hydrocarbon levels in milk collected near potential contamination sources. J. Agric. Food Chem. 2002;50:4640–4642
  8. Grova N, Feidt C, Laurent C, Rychen G. [14C] Milk, urine and faeces excretion kinetics in lactating goats after an oral administration of [14C]polycyclic aromatic hydrocarbons. Int. Dairy J. 2002;12:1025–1031
  9. Grova N, Monteau F, Le Bizec B, Feidt C, Andre F, Rychen G. Determination of phenanthrene and hydroxyphenanthrenes in various biological matrices at trace levels using gas chromatography-mass spectrometry. J. Anal. Toxicol. 2005;29:175–181
  10. Jacob J, Grimmer G. Metabolism and excretion of polycyclic aromatic hydrocarbons in rat and in human. Cent. Eur. J. Public Health. 1996;4:33–39
  11. Jacob J, Seidel A. Biomonitoring of polycyclic aromatic hydrocarbons in human urine. J. Chromatogr. B. 2002;778:31–47
  12. Lafontaine M, Payan JP, Delsaut P, Morele Y. Polycyclic aromatic hydrocarbon exposure in an artificial shooting target factory: Assessment of 1-hydroxypyrene urinary excretion as a biological indicator of exposure. Ann. Occup. Hyg. 2000;44:89–100
  13. Raszyk J, Neca J, Salava J, Palac J. A pilot study of 1-hydroxypyrene in the urine of pigs and cows. Vet. Med. (Praha). 1999;44:359–363
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  16. US EPA. 1993. Provisional guidance for quantitative risk assessment of polycyclic aromatic hydrocarbons. EPA/600/R-93/089, US Environmental Protection Agency, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH.
  17. Van de Wiel JA, Fijneman PH, Duijf CM, Anzion RB, Theuws JL, Bos RP. Excretion of benzo[a]pyrene and metabolites in urine and feces of rats: Influence of route of administration, sex and long-term ethanol treatment. Toxicology. 1993;80:103–115
  18. Waidyanatha S, Zheng Y, Rappaport SM. Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometry. Chem. Biol. Interact. 2003;145:165–174
  19. Werck-Reichhart D, Feyereisen R. Cytochromes P450: A success story. Genome Biology. 2000;1:reviews3003.1–3003.9
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PII: S0022-0302(07)70073-5

doi: 10.3168/jds.2006-806

Journal of Dairy Science
Volume 90, Issue 6 , Pages 2624-2629 , June 2007

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