Journal of Dairy Science
Volume 90, Issue 2 , Pages 541-546 , February 2007

Bovine α-Lactalbumin Stimulates Mucus Metabolism in Gastric Mucosa

  • Y. Ushida

      Affiliations

    • Biochemical Research Laboratory, Morinaga Milk Industry Co. Ltd., Zama, Kanagawa 228-8583, Japan
    • Corresponding Author InformationCorresponding author.
    • ,
  • Y. Shimokawa

      Affiliations

    • Biochemical Research Laboratory, Morinaga Milk Industry Co. Ltd., Zama, Kanagawa 228-8583, Japan
    • ,
  • T. Toida

      Affiliations

    • Biochemical Research Laboratory, Morinaga Milk Industry Co. Ltd., Zama, Kanagawa 228-8583, Japan
    • ,
  • H. Matsui

      Affiliations

    • Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    • ,
  • M. Takase

      Affiliations

    • Biochemical Research Laboratory, Morinaga Milk Industry Co. Ltd., Zama, Kanagawa 228-8583, Japan

Received 2 July 2006 ,Accepted 26 September 2006.

References 

  1. Allen A, Flemström G. Gastroduodenal mucus bicarbonate barrier: Protection against acid and pepsin. Am. J. Physiol. Cell Physiol. 2005;288:C1–19
  2. Azuumi Y, Ohara S, Ishihara K, Okabe H, Hotta K. Correlation of quantitative changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats. Gut. 1980;21:533–536
  3. Coleman RA, Grix SP, Head SA, Louttit JB, Mallett A, Sheldrick RL. A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins. 1994;47:151–168
  4. Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 1994;46:205–229
  5. Daugherty DF, Lucey MR, Yamada T. Gastric secretion. Textbook of Gastroenterology.. Philadelphia, PA: J.B. Lippincott; 1991;Vol. 1 Pages 233–264
  6. Ding M, Kinoshita Y, Kishi K, Nakata H, Hassan S, Kawanami C, et al. Distribution of prostaglandin E receptors in the rat gastrointestinal tract. Prostaglandins. 1997;53:199–216
  7. Gill HS, Cross ML. Anticancer properties of bovine milk. Br. J. Nutr. 2000;84:S161–S166
  8. Håkansson A, Svensson M, Mossberg AK, Sabharwal H, Linse S, Lazou I, et al. A folding variant of α-lactalbumin with bactericidal activity against Streptococcus pneumoniae. Mol. Microbiol. 2000;35:589–600
  9. Håkansson A, Zhivotovsky B, Orrenius S, Sabharwal H, Svanborg C. Apoptosis induced by a human milk protein. Proc. Natl. Acad. Sci. USA. 1995;92:8064–8068
  10. Hassan S, Kinoshita Y, Min D, Nakata H, Kishi K, Matsushima Y, et al. Presence of prostaglandin EP4 receptor gene expression in a rat gastric mucosal cell line. Digestion. 1996;57:196–200
  11. Kobayashi I, Kawano S, Tsuji S, Matsui H, Nakama A, Sawaoka H, et al. RGM1, a cell line derived from normal gastric mucosa of rat. In Vitro Cell. Dev. Biol. Anim. 1996;32:259–261
  12. Matsumoto H, Shimokawa Y, Ushida Y, Toida T, Hayasawa H. New biological function of bovine α-lactalbumin: Protective effect against ethanol- and stress-induced gastric mucosal injury in rats. Biosci. Biotechnol. Biochem. 2001;65:1104–1111
  13. Miller TA. Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms. Am. J. Physiol. 1983;245:G601–G623
  14. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA. 1994;90:11693–11697
  15. Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: Structures, properties, and functions. Physiol. Rev. 1999;79:1193–1226
  16. Pellegrini A, Thomas U, Bramaz N, Hunziker P, von Fellenberg R. Isolation and identification of three bactericidal domains in the bovine α-lactalbumin molecule. Biochim. Biophys. Acta. 1999;1426:439–448
  17. Permyakov EA, Berliner LJ. α-Lactalbumin: Structure and function. FEBS Lett. 2000;473:269–274
  18. Powell WS. Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica. Methods Enzymol. 1982;86:467–477
  19. Shah NP. Effects of milk-derived bioactives: An overview. Br. J. Nutr. 2000;84:S3–10
  20. Shimamoto C, Hirata I, Umegaki E, Takiuchi H, Hiraike Y, Fujiwara S, et al. Gastric mucosal cell protection by epidermal growth factor in primary monolayer culture of guinea pig gastric mucous cells. J. Gastroenterol. 2003;38:727–733
  21. Silen W. Gastric mucosal defense and repair. Physiology of the Gastrointestinal Tract. 2nd ed. New York, NY: Raven Press; 1987;Pages 1055–1069
  22. Svensson M, Håkansson A, Mossberg AK, Linse S, Svanborg C. Conversion of α-lactalbumin to a protein inducing apoptosis. Proc. Natl. Acad. Sci. USA. 2000;97:4221–4226
  23. Terano A, Hiraishi H, Ota S, Sugimoto T. Geranylgeranylacetone, a novel anti-ulcer drug, stimulates mucus synthesis and secretion in rat gastric cultured cells. Digestion. 1986;33:206–210
  24. Ushida Y, Shimokawa Y, Matsumoto H, Toida T, Hayasawa H. Effects of bovine α-lactalbumin on gastric defense mechanisms in naive rats. Biosci. Biotechnol. Biochem. 2003;67:577–583
  25. Wilson DE. Role of prostaglandins in gastroduodenal mucosal protection. J. Clin. Gastroenterol. 1991;13:S65–S71

PII: S0022-0302(07)71537-0

doi: 10.3168/jds.S0022-0302(07)71537-0

Journal of Dairy Science
Volume 90, Issue 2 , Pages 541-546 , February 2007

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