Journal of Dairy Science
Volume 90, Issue 7 , Pages 3143-3152 , July 2007

Characterization of Carbohydrate Structures of Bovine MUC15 and Distribution of the Mucin in Bovine Milk

Received 6 February 2007 ,Accepted 6 March 2007.

References 

  1. Abdullah KM, Udoh EA, Shewen PE, Mellors A. A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins. Infect. Immun. 1992;60:56–62
  2. Benfeldt C, Larsen LB, Rasmussen JT, Andreasen PA, Petersen TE. Isolation and characterization of plasminogen and plasmin from bovine milk. Int. Dairy J. 1995;5:517–592
  3. Chacko BK, Appukuttan PS. Peanut (Arachis hypogaea) lectin recognizes α-linked galactose, but not N-acetyllactosamine in N-linked oligosaccharide terminals. Int. J. Biol. Macromol. 2001;28:365–371
  4. Christlet T, Veluraja K. Database analysis of O-glycosylation sites in proteins. Biophys. J. 2001;80:952–960
  5. Cladman WM, Watt MA, Dini JP, Mellors A. The Pasteurella haemolytica O-sialoglycoprotein endopeptidase is inhibited by zinc ions and does not cleave fetuin. Biochem. Biophys. Res. Commun. 1996;220:141–146
  6. Crowley JF, Goldstein IJ, Arnarp J, Lönngren J. Carbohydrate binding studies on the lectin from Datura stramonium seeds. Arch. Biochem. Biophys. 1984;231:524–533
  7. Cummings RD. Use of lectins in analysis of glycoconjugates. Methods Enzymol. 1994;230:66–86
  8. Endo Y, Kobata A. Partial purification and characterization of an endo-alpha-N-acetylgalactosaminidase from the culture of medium of Diplococcus pneumoniae. J. Biochem. (Tokyo). 1976;80:1–8
  9. Gerken TA, Zhang J, Levine J, Elhammer A. Mucin core O-glycosylation is modulated by neighboring residue glycosylation status. Kinetic modeling of the site-specific glycosylation of the apoporcine submaxillary mucin tandem repeat by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases T1 and T2. J. Biol. Chem. 2002;277:49850–49862
  10. Hanisch FG. O-Glycosylation of the mucin type. Biol. Chem. 2001;382:143–149
  11. Hanisch FG, Uhlenbruck G, Peter-Katalinic J, Egge H, Dabrowski J, Dabrowski U. Structures of neutral O-linked polylactosaminoglycans on human skim milk mucins. A novel type of linearly extended poly-N-acetyllactosamine backbones with Gal beta(1–4)GlcNAc beta(1–6) repeating units. J. Biol. Chem. 1989;264:872–883
  12. Hart ML, Saifuddin M, Uemura K, Bremer EG, Hooker B, Kawasaki T, et al. High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1. AIDS Res. Hum. Retroviruses. 2002;18:1311–1317
  13. Heegaard CW, Larsen LB, Rasmussen LK, Hojberg K-E, Petersen TE, Andreasen PA. Plasminogen activation system in human milk. J. Pediatr. Gastroenterol. Nutr. 1997;25:159–166
  14. Ho JJ, Jaituni RS, Crawley SC, Yang SC, Gum JR, Kim YS. N-Glycosylation is required for the surface localization of MUC17 mucin. Int. J. Oncol. 2003;23:585–592
  15. Hvarregaard J, Andersen MH, Berglund L, Rasmussen JT, Petersen TE. Characterization of glycoprotein PAS-6/7 from membranes of bovine milk fat globules. Eur. J. Biochem. 1996;240:628–636
  16. Julenius K, Mølgaard A, Gupta R, Brunak S. Prediction, conservation analysis and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology. 2005;15:153–164
  17. Knibbs RN, Goldstein IJ, Ratcliffe RM, Shibuya N. Characterization of the carbohydrate binding specificity of the leukoagglutinating lectin from Maackia amurensis. J. Biol. Chem. 1991;266:83–88
  18. Kvistgaard AS, Pallesen LT, Arias CF, Lopez S, Petersen TE, Heegaard CW, et al. Inhibitory effects of human and bovine milk constituents on rotavirus infections. J. Dairy Sci. 2004;87:4088–4096
  19. Lotan R, Skutelsky E, Danon D, Sharon N. The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea). J. Biol. Chem. 1975;250:8518–8523
  20. Mather IH, Tamplin CB, Irving MG. Separation of the proteins of bovine milk-fat-globule membrane by electrofocusing with retention of enzymatic and immunological activity. Eur. J. Biochem. 1980;110:327–336
  21. Moniaux N, Escande F, Porchet N, Aubert JP, Batra SK. Structural organization and classification of the human mucin genes. Front. Biosci. 2001;6:d1192–d1206
  22. Pallesen LT, Andersen MH, Nielsen RL, Berglund L, Petersen TE, Rasmussen LK, et al. Purification of MUC1 from bovine milk-fat globules and characterization of a corresponding full-length cDNA clone. J. Dairy Sci. 2001;84:2591–2598
  23. Pallesen LT, Berglund L, Rasmussen LK, Petersen TE, Rasmussen JT. Isolation and characterization of MUC15, a novel cell membrane-associated mucin. Eur. J. Biochem. 2002;269:2755–2763
  24. Peterson JA, Patton S, Hamosh M. Glycoproteins of the human milk fat globule in the protection of the breast-fed infant against infections. Biol. Neonate. 1998;74:143–162
  25. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol. Rev. 2006;86:245–278
  26. Schacterle GR, Pollack RL. A simplified method for the quantitative assay of small amounts of protein in biological material. Anal. Biochem. 1973;51:654–655
  27. Shibuya N, Goldstein IJ, Broekaert WF, Nsimba-Lubaki M, Peeters B, Peumans WJ. The elderberry (Sambucus nigra L.) bark lectin recognizes the Neu5Ac(α2–6)Gal/GalNAc sequence. J. Biol. Chem. 1987;262:1596–1601
  28. Shibuya LT, Goldstein IJ, Van Damme EJM, Peumans WJ. Binding properties of a mannose-specific lectin from the snowdrop (Galanthus nivalis) bulb. J. Biol. Chem. 1988;263:728–734
  29. Tretter V, Altmann F, Marz L. Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase F cannot release glycans with fucose attached alpha 1–3 to the asparagine-linked N-acetyl-glucosamine residue. Eur. J. Biochem. 1991;199:647–652
  30. Varki A. Biological roles of oligosaccharides: All of the theories are correct. Glycobiologi. 1993;3:97–130
  31. Yamashita K, Totani K, Ohkura T, Takasaki S, Goldstein IJ, Kobata A. Carbohydrate binding properties of complex-type oligosaccharides on immobilized Datura stramonium lectin. J. Biol. Chem. 1987;262:1602–1607

PII: S0022-0302(07)71762-9

doi: 10.3168/jds.2007-0082

Journal of Dairy Science
Volume 90, Issue 7 , Pages 3143-3152 , July 2007

Article Tools

* Image Usage & Resolution