Journal of Dairy Science
Volume 90, Issue 9 , Pages 4022-4032 , September 2007

Invited Review: New Perspectives on the Roles of Nutrition and Metabolic Priorities in the Subfertility of High-Producing Dairy Cows1

  • L.M. Chagas

      Affiliations

    • Dexcel, Private Bag 3221, Hamilton, New Zealand
    • Corresponding Author InformationCorresponding author.
    • ,
  • J.J. Bass

      Affiliations

    • Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1003, New Zealand
    • ,
  • D. Blache

      Affiliations

    • The School of Animal Biology, University of Western Australia, 37 Stirling Highway, Crawley, 6009, Australia
    • ,
  • C.R. Burke

      Affiliations

    • Dexcel, Private Bag 3221, Hamilton, New Zealand
    • ,
  • J.K. Kay

      Affiliations

    • Dexcel, Private Bag 3221, Hamilton, New Zealand
    • ,
  • D.R. Lindsay

      Affiliations

    • The School of Animal Biology, University of Western Australia, 37 Stirling Highway, Crawley, 6009, Australia
    • ,
  • M.C. Lucy

      Affiliations

    • Division of Animal Sciences, University of Missouri, Columbia 65211
    • ,
  • G.B. Martin

      Affiliations

    • The School of Animal Biology, University of Western Australia, 37 Stirling Highway, Crawley, 6009, Australia
    • ,
  • S. Meier

      Affiliations

    • Dexcel, Private Bag 3221, Hamilton, New Zealand
    • ,
  • F.M. Rhodes

      Affiliations

    • 21 Scotsman Valley Road, Hamilton, New Zealand
    • ,
  • J.R. Roche

      Affiliations

    • University of Tasmania, PO Box 3523, Burnie, Tasmania, Australia 7320
    • ,
  • W.W. Thatcher

      Affiliations

    • Department of Animal Sciences, University of Florida, Gainesville 32610
    • ,
  • R. Webb

      Affiliations

    • University of Nottingham, Division of Agriculture and Environmental Sciences, School of Biosciences, Loughborough, Leicestershire, LE12 5RD, United Kingdom

Received 18 December 2006 ,Accepted 2 May 2007.

References 

  1. Adamiak SJ, Mackie K, Watt RG, Webb R, Sinclair KD. Impact of nutrition on oocyte quality: Cumulative effects of body composition and diet leading to hyperinsulinaemia in cattle. Biol. Reprod. 2005;73:918–926
  2. Adamiak SJ, Powell K, Rooke JA, Webb R, Sinclair KD. Body composition, dietary carbohydrates and fatty acids determine post-fertilisation development of bovine oocytes in vitro. Reproduction. 2006;131:247–258
  3. Ambrose DJ, Kastelic JP, Corbett R, Pitney PA, Petit HV, Small JA, et al. Lower pregnancy losses in lactating dairy cows fed a diet enriched in alpha-linolenic acid. J. Dairy Sci. 2006;89:3066–3074
  4. Andrew SM, Waldo DR, Erdman RA. Direct analysis of body composition of dairy cows at three physiological stages. J. Dairy Sci. 1994;77:3022–3033
  5. Armstrong DG, Gong JG, Gardner JO, Baxter G, Hogg CO, Webb R. Steroidogenesis in bovine granulosa cells: The effect of short-term changes in dietary intake. Reproduction. 2002;123:371–378
  6. Armstrong DG, Gong JG, Webb R. Interactions between nutrition and ovarian activity in cattle: Physiological, cellular and molecular mechanisms. Reprod. Suppl. 2003;61:403–414
  7. Armstrong DG, McEvoy TG, Baxter G, Robinson JJ, Hogg CO, Woad KJ, et al. Effect of dietary energy and protein on bovine follicular dynamics and embryo production in vitro: Associations with the ovarian insulin-like growth factor system. Biol. Reprod. 2001;64:1624–1632
  8. Augustin R, Pocar P, Wrenzycki C, Niemann H, Fischer B. Mitogenic and anti-apoptotic activity of insulin on bovine embryos produced in vitro. Reproduction. 2003;126:91–99
  9. Baile CA, Buonomo FC. Growth hormone-releasing factor effects on pituitary function, growth, and lactation. J. Dairy Sci. 1987;70:467–473
  10. Bartness TJ, Kay Song C, Shi H, Bowers RR, Foster MT. Brain-adipose tissue cross talk. Proc. Nutr. Soc. 2005;64:53–64
  11. Bauman DE, Currie WB. Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis. J. Dairy Sci. 1980;63:1514–1529
  12. Baumgard LH, Kay JK, Moore CE, Roche JR, VanBaale MJ, Rhoads RP. Regulating milk fat synthesis: Potential on-farm applications of basic science. Proc. N.Z. Soc. Anim. Prod. 2005;65:33–39
  13. Beam SW, Butler WR. Effects of energy balance on follicular development and first ovulation in postpartum dairy cows. J. Reprod. Fertil. Suppl. 1999;54:411–424
  14. Berry DP, Buckley F, Dillon P, Evans RD, Rath M, Veerkamp RF. Genetic relationships among body condition score, body weight, milk yield, and fertility in dairy cows. J. Dairy Sci. 2003;86:2193–2204
  15. Bilby TR, Sozzi A, Lopez MM, Silvestre FT, Ealy AD, Staples CR, et al. Pregnancy, bovine somatotropin, and dietary n-3 fatty acids in lactating dairy cows: S Ovarian F I.conceptus, and growth hormone-insulin-like growth factor system responses. J. Dairy Sci. 2006;89:3360–3374
  16. Blache D, Chagas LM, Martin GB. Nutritional inputs into the reproductive neuroendocrine control system—A multidimensional perspective. Reprod. Suppl. 2007;64:124–139
  17. Blache D, Zhang S, Martin GB. Dynamic and integrative aspects of the regulation of reproduction by metabolic status in male sheep. Reprod. Nutr. Dev. 2006;46:379–390
  18. Boken SL, Staples CR, Sollenberger LE, Jenkins TC, Thatcher WW. Effect of grazing and fat supplementation on production and reproduction of Holstein cows. J. Dairy Sci. 2005;88:4258–4272
  19. Borwick SC, Rhind SM, McMillen SR, Racey PA. Effect of undernutrition of ewes from the time of mating on fetal ovarian development in mid gestation. Reprod. Fertil. Dev. 1997;9:711–715
  20. Buckley F, O'Sullivan K, Mee JF, Evans RD, Dillon P. Relationship among milk yield, body condition, cow weight and reproduction in spring-calved Holstein-Friesians. J. Dairy Sci. 2003;86:2308–2319
  21. Burke CR, McDougall S, Macmillan KL. Effects of breed and calving live weight on postpartum ovarian activity in pasture-fed dairy heifers. Proc. N.Z. Soc. Anim. Prod. 1995;55:76–78
  22. Burke CR, Roche JR, Aspin PW, Lee JM. A nutrient-signalling effect of grain feeding on postpartum anovulatory intervals in matture dairy cows. Proc. N.Z. Soc. Anim. Prod. 2006;66:334–338
  23. Burke CR, Roche JR, Aspin PW, Lee JM, Taufa VK. Effect of pre- and postpartum pasture feeding intakes on postpartum anoestrous intervals in dairy cows. Proc. N.Z. Soc. Anim. Prod. 2005;65:221–224
  24. Butler WR, Smith RD. Interrelationships between energy balance and postpartum reproductive function in dairy cows. J. Dairy Sci. 1989;72:767–783
  25. Canfield RW, Sniffen CJ, Butler WR. Effects of excess degradable protein on postpartum reproduction and energy balance in dairy cattle. J. Dairy Sci. 1990;73:2342–2349
  26. Chagas LM, Gore PJS, Meier S, Macdonald KA, Verkerk GA. Effect of mono propylene glycol on luteinizing hormone, metabolites and postpartum anovulatory intervals in dairy heifers. J. Dairy Sci. 2007;90:1168–1175
  27. Chagas LM, Gore PJS, Verkerk GA, Macdonald KA, Blache D. Restricted postpartum feeding in grazing dairy heifers decreases milk production but does not lengthen anoestrous interval. Proc. N.Z. Soc. Anim. Prod. 2007;67:255–260
  28. Chagas LM, Rhodes FM, Blache D, Gore PJS, Macdonald KA, Verkerk GA. Precalving feeding and body condition effects on metabolic responses and postpartum anestrus interval in grazing primiparous dairy cows. J. Dairy Sci. 2006;89:1981–1989
  29. Collard BL, Boettcher PJ, Dekkers JC, Petitclerc D, Schaeffer LR. Relationships between energy balance and health traits of dairy cattle in early lactation. J. Dairy Sci. 2000;83:2683–2690
  30. Diskin MG, Mackey DR, Roche JF, Sreenan JM. Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle. Anim. Reprod. Sci. 2003;78:345–370
  31. Flint APF, Brotherstone S, Coffey MP, Royal MD, Santarossa J, Simm G, et al. The UK Fertility Index. In: Proc. British Cattle Conference. The British Cattle Breeders Club,ed. Devon, UK: British Cattle Breeders Club; 2004;p. 59–62
  32. Fouladi-Nashta AA, Campbell KH. Dissociation of oocyte nuclear and cytoplasmic maturation by the addition of insulin in cultured bovine antral follicles. Reproduction. 2006;131:449–460
  33. Fouladi-Nashta AA, Gutierrez CG, Garnsworthy PC, Webb R. Effects of dietary carbohydrate source on oocyte/embryo quality and development in high yielding lactating dairy cattle. Biol. Reprod. 2005 Special Edition 1;70:244;Abstr
  34. Garnsworthy PC. Body condition score in dairy cows: Targets for production and fertility. In:  Garnsworthy PC,  Wiseman J editor. Recent Advances in Animal Nutrition 2006. Nottingham, UK: Nottingham University Press; 2007;p. 61–86
  35. Garnsworthy PC, Topps JH. The effect of body condition score at calving on their food intake and performance when given complete diets. Anim. Prod. 1982;35:113–119
  36. Gibb MJ, Ivings WE, Dhanoa MS, Sutton JD. Changes in body components of autumn-calving Holstein-Friesian cows over the first 29 weeks of lactation. Anim. Prod. 1992;55:339–360
  37. Goff JP. Major advances in our understanding of nutritional influences on bovine health. J. Dairy Sci. 2006;89:1292–1301
  38. Gong JG, Bramley T, Webb R. The effect of recombinant bovine somatotropin on ovarian function in heifers: Follicular populations and peripheral hormones. Biol. Reprod. 1991;45:941–949
  39. Gong JG, Lee WJ, Garnsworthy PC, Webb R. Effect of dietary-induced increases in circulating insulin concentrations during the early postpartum period on reproductive function in dairy cows. Reproduction. 2002;123:419–427
  40. Grainger C, Wilhems GD, McGowan AA. Effects of body condition at calving and the level of feeding in early lactation on milk production of dairy cows. Aust. J. Exp. Agric. Anim. Husb. 1982;22:9–17
  41. Gutierrez CG, Campbell BK, Webb R. Development of a long-term bovine granulosa cell culture system: Induction and maintenance of estradiol production, response to follicle-stimulating hormone, and morphological characteristics. Biol. Reprod. 1997;56:608–616
  42. Gutierrez CG, Gong JG, Bramley TA, Webb R. Selection on the predicted breeding value for milk production delays ovulation independently of changes in follicular development, milk production and body weight. Anim. Reprod. Sci. 2006;95:193–205
  43. Gutierrez CG, Ralph JH, Telfer EE, Wilmut I, Webb R. Growth and antrum formation of bovine preantral follicles in long-term culture in vitro. Biol. Reprod. 2000;62:1322–1328
  44. Harris, B. L. 2005. Multiple trail fertility model for the national genetic evaluation. Livestock Improvement Corporation. 1–24. www.aeu.org.nz/page.cfm?id=59&nid=35
  45. Harris BL, Kolver ES. Review of holsteinization on intensive pastoral dairy farming in New Zealand. J. Dairy Sci. 2001;84(E Suppl):E56–E61
  46. Horan B, Mee JF, Rath M, O’Connor P, Dillon P. The effect of strain of Holstein-Friesian cow and feeding system on reproductive performance in seasonal-calving milk production systems. Anim. Sci. 2004;79:453–468
  47. Kacsoh B. Endocrine Physiology. New York, NY: McGraw Hill Book Co.; 2000;
  48. Kadokawa H, Martin GB. A new perspective on management of reproduction in dairy cows: The need for detailed metabolic information, an improved selection index and extended lactation. J. Reprod. Dev. 2006;52:161–168
  49. Kendall NR, Gutierrez CG, Scaramuzzi RJ, Baird DT, Webb R, Campbell BK. Direct in vivo effects of leptin on ovarian steroidogenesis in sheep. Reproduction. 2004;128:757–765
  50. Kolver ES, Roche JR, Aspin PW. Plasma insulin, growth hormone and IGF-1 concentrations of Holstein-Friesian Cows of divergent genotype offered varying level of concentrate in early lactation. Proc. N.Z. Soc. Anim. Prod. 2006;66:403–408
  51. Lamote I, Meyer E, Massart-Leen AM, Burvenich C. Sex steroids and growth factors in the regulation of mammary gland proliferation, differentiation, and involution. Steroids. 2004;69:145–159
  52. Lee SJ. Regulation of muscle mass by myostatin. Annu. Rev. Cell Dev. Biol. 2004;20:61–86
  53. Lopez H, Satter LD, Wiltbank MC. Relationship between level of milk production and estrous behavior of lactating dairy cows. Anim. Reprod. Sci. 2004;81:209–223
  54. Lucy MC. Mechanisms linking nutrition and reproduction in postpartum cows. Reproduction. 2003;61:415–427
  55. Lucy MC. Fertility in high-producing dairy cows: Reasons for decline and corrective strategies for sustainable improvement. Reprod. Suppl. 2007;64:237–254
  56. Lyons DT, Freeman AE, Kuck AL. Genetics of health traits in Holstein cattle. J. Dairy Sci. 1991;74:1092–1100
  57. Macdonald KA, Roche J. Condition scoring made easy. Condition Scoring Dairy Herds. Hamilton, New Zealand: Dexcel Ltd.; 2004;4–7
  58. Macdonald KA, Verkerk GA, Penno JW. Validation of body condition scoring by using ultrasound measurements of subcutaneous fat. Proc. N.Z. Soc. Anim. Prod. 1999;59:177–179
  59. McNeill RE, Diskin MG, Sreenan JM, Morris DG. Associations between milk progesterone concentration on different days and with embryo survival during the early luteal phase in dairy cows. Theriogenology. 2006;65:1435–1441
  60. McNeilly AS. Lactational control of reproduction. Reprod. Fertil. Dev. 2001;13:583–590
  61. Mitchell MD, Osepchook CC, Leung KC, McMahon CD, Bass JJ. Myostatin is a human placental product that regulates glucose uptake. J. Clin. Endocrinol. Metab. 2006;91:1434–1437
  62. Nicholas B, Alberio R, Fouladi-Nashta AA, Webb R. Relationship between low-molecular-weight insulin-like growth factor-binding proteins, caspase-3 activity, and oocyte quality. Biol. Reprod. 2005;72:796–804
  63. National Research Council. Nutrient Requirements of Dairy Cattle. Washington, DC: Natl. Acad. Press; 2001;
  64. Okamura H, Ohkura S. Neuroendocrine control of reproductive function in ruminants. Anim. Sci. J. 2007;78:105–111
  65. Pfaff D. Hormone-driven mechanisms in the central nervous system facilitate the analysis of mammalian behaviours. J. Endocrinol. 2005;184:447–453
  66. Philipsson J, Lindé B. Experiences of including reproduction and health traits in Scandinavian dairy cattle breeding programmes. Livest. Prod. Sci. 2003;83:99–112
  67. Rae MT, Palassio S, Kyle CE, Brooks AN, Lea RG, Miller DW, et al. Effect of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses. Reproduction. 2001;122:915–922
  68. Rawson JA, Scott CJ, Pereira A, Jakubowska A, Clarke IJ. Noradrenergic projections from the A1 field to the preoptic area in the brain of the ewe and Fos responses to oestrogen in the A1 cells. J. Neuroendocr. 2001;13:129–138
  69. Rhind SM, Elston DA, Jones JR, Rees JR, McMillen SR, Gunn RG. Effects of restriction of growth and development of Brecon Cheviot ewe lambs on subsequent lifetime reproductive performance. Small Rumin. Res. 1998;30:121–126
  70. Rhodes FM, Chagas LM, Clark BA, Verkerk GA. Effect of dietary intake on steroid feedback on release of luteinizing hormone in ovariectomized cows. Reprod. Fertil. Dev. 2003;15:11–17
  71. Roche JF. The effect of nutritional management of the dairy cow on reproductive efficiency. Anim. Reprod. Sci. 2006;96:282–296
  72. Roche JR, Berry DP, Kolver ES. Holstein-Friesian strain and feed effects on milk production, body weight, and body condition score profiles in grazing dairy cows. J. Dairy Sci. 2006;89:3532–3543
  73. Roche JR, Dillon PG, Stockdale CR, Baumgard LH, VanBaale MJ. Relationships among international body condition scoring systems. J. Dairy Sci. 2004;87:3076–3079
  74. Roche JR, Macdonald KA, Burke CR, Lee JM, Berry DP. Associations among body condition score, body weight and reproductive performance in seasonal-calving dairy cattle. J. Dairy Sci. 2007;90:376–391
  75. Royal MD, Darwash AO, Flint APF, Webb R, Woolliams JA, Lamming GE. Declining fertility in dairy cattle: Changes in traditional and endocrine parameters of fertility. Anim. Sci. 2000;70:487–501
  76. Royal MD, Pryce JE, Woolliams JA, Flint APF. The genetic relationship between commencement of luteal activity and calving interval, body condition score, production and linear type traits in Holstein-Friesian dairy cattle. J. Dairy Sci. 2002;85:3071–3080
  77. Sinclair KD, Kuran M, Gebbie FE, Webb R, McEvoy TG. Nitrogen metabolism and fertility in cattle: II. Development of oocytes recovered from heifers offered diets differing in their rate of nitrogen release in the rumen. J. Anim. Sci. 2000;78:2670–2680
  78. Sinclair KD, Webb R. Fertility in the modern dairy heifer. In:  Garnsworthy PC editors. Calf and Heifer Rearing. Nottingham, UK: Nottingham University Press; 2005;p. 277–306
  79. Sotiropoulos A, Ohanna M, Kedzia C, Menon RK, Kopchick JJ, Kelly PA, et al. Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. Proc. Natl. Acad. Sci. USA. 2006;103:7315–7320
  80. Spicer LJ, Francisco CC. Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis. Biol. Reprod. 1998;58:207–212
  81. Spicer LJ, Voge JL, Allen DT. Insulin-like growth factor-II stimulates steroidogenesis in cultured bovine thecal cells. Mol. Cell. Endocrinol. 2004;227:1–7
  82. Staples CR, Burke JM, Thatcher WW. Influence of supplemental fats on reproductive tissues and performance of lactating cows. J. Dairy Sci. 1998;81:856–871
  83. Strassman G, Liang LF, Toupouzis S. Methods for treating diabetes. US Patent 20020031517. assignee: Metamorphix Inc.; 2002;
  84. Tena-Sempere M. Exploring the role of ghrelin as novel regulator of gonadal function. Growth Horm. IGF Res. 2005;15:83–88
  85. Underwood EJ, Suttle NF. The Mineral Nutrition of Livestock. New York, NY: CABI Publ.; 2001;
  86. Wade GN, Jones JE. Neuroendocrinology of nutritional infertility. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004;287:R1277–R1296
  87. Waltner SS, McNamara JP, Hillers JK. Relationships of body condition score to production variables in high producing Holstein dairy cattle. J. Dairy Sci. 1993;76:3410–3419
  88. Watson AJ, Westhusin ME, Winger QA. IGF paracrine and autocrine interactions between conceptus and oviduct. J. Reprod. Fertil. Suppl. 1999;54:303–315
  89. Webb R, Garnsworthy PC, Gong JG, Armstrong DG. Control of follicular growth: Local interactions and nutritional influences. J. Anim. Sci. 2004;82(E Suppl):E63–E74
  90. Webb R, Nicholas B, Gong JG, Campbell BK, Gutierrez CG, Garverick HA, et al. Mechanisms regulating follicular development and selection of the dominant follicle. Reprod. Suppl. 2003;61:71–90
  91. Wiltbank M, Lopez H, Sartori R, Sangsritavong S, Gumen A. Changes in reproductive physiology of lactating dairy cows due to elevated steroid metabolism. Theriogenology. 2006;65:17–29
  92. Wright IA, Russel AJF. Partition of fat, body composition and body condition score in mature cows. Anim. Prod. 1984;38:23–32
  93. Wynne K, Stanley S, McGowan B, Bloom S. Appetite control. J. Endocrinol. 2005;184:291–318
  94. Zieba DA, Amstalden M, Williams GL. Regulatory roles of leptin in reproduction and metabolism: A comparative review. Domest. Anim. Endocrinol. 2005;29:166–185
  95. Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN, et al. Induction of cachexia in mice by systemically administered myostatin. Science. 2002;296:1486–1488

PII: S0022-0302(07)71859-3

doi: 10.3168/jds.2006-852

Journal of Dairy Science
Volume 90, Issue 9 , Pages 4022-4032 , September 2007

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