Journal of Dairy Science
Volume 90 , Pages E55-E65 , June 2007

Regulation of Gene Expression in the Bovine Mammary Gland by Ovarian Steroids1

  • E.E. Connor

      Affiliations

    • Bovine Functional Genomics Laboratory, USDA, ARS, Beltsville, MD 20705-2350
    • Corresponding Author InformationCorresponding author.
    • ,
  • M.J. Meyer

      Affiliations

    • Mammary Biology and Tumorigenesis Laboratory, National Institutes of Health, National Cancer Institute, Bethesda, MD 20892-4254
    • ,
  • R.W. Li

      Affiliations

    • Bovine Functional Genomics Laboratory, USDA, ARS, Beltsville, MD 20705-2350
    • ,
  • M.E. Van Amburgh

      Affiliations

    • Department of Animal Science, Cornell University, Ithaca, NY 14853-4801
    • ,
  • Y.R. Boisclair

      Affiliations

    • Department of Animal Science, Cornell University, Ithaca, NY 14853-4801
    • ,
  • A.V. Capuco

      Affiliations

    • Bovine Functional Genomics Laboratory, USDA, ARS, Beltsville, MD 20705-2350

Received 24 July 2006 ,Accepted 26 October 2006.

  • Image Result

    Mechanisms of steroid hormone receptor action on gene transcription. AP-1 = activator protein-1 response element; E = estrogen; HRE = hormone response element; P = progesterone; RNA Pol = RNA polymera

    Mechanisms of steroid hormone receptor action on gene transcription. AP-1 = activator protein-1 response element; E = estrogen; HRE = hormone response element; P = progesterone; RNA Pol = RNA polymerase.

  • Image Result
    Proposed paracrine pathway of (A) estrogen and (B) progesterone action on mammary epithelial cell proliferation in ruminants. E = estrogen; EGF = epidermal growth factor; ERα = estrogen receptor α; FG

    Proposed paracrine pathway of (A) estrogen and (B) progesterone action on mammary epithelial cell proliferation in ruminants. E = estrogen; EGF = epidermal growth factor; ERα = estrogen receptor α; FGF = fibroblast growth factors; HGF = hepatocyte growth factor; IGF-I = insulin-like growth factor-I; KGF = keratinocyte growth factor; MEC = mammary epithelial cell; P = progesterone; PR-B = progesterone receptor B; Wnt-4 = signaling molecule.

PII: S0022-0302(07)72060-X

doi: 10.3168/jds.2006-466

Journal of Dairy Science
Volume 90 , Pages E55-E65 , June 2007

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