Journal of Dairy Science
Volume 90, Issue 1 , Pages 66-74 , January 2007

Inhibitory Activities of Bovine Macromolecular Whey Proteins on Rotavirus Infections In Vitro and In Vivo

  • A. Bojsen

      Affiliations

    • Protein Chemistry Laboratory, University of Aarhus, 8000 Aarhus C, Denmark
    • ,
  • J. Buesa

      Affiliations

    • Department of Microbiology, School of Medicine, University of Valencia and Hospital Clínico Universitario, Valencia, Spain
    • ,
  • R. Montava

      Affiliations

    • Department of Microbiology, School of Medicine, University of Valencia and Hospital Clínico Universitario, Valencia, Spain
    • ,
  • A.S. Kvistgaard

      Affiliations

    • Arla Foods, Aarhus, 8260 Viby J, Denmark
    • ,
  • M.B. Kongsbak

      Affiliations

    • Protein Chemistry Laboratory, University of Aarhus, 8000 Aarhus C, Denmark
    • ,
  • T.E. Petersen

      Affiliations

    • Protein Chemistry Laboratory, University of Aarhus, 8000 Aarhus C, Denmark
    • ,
  • C.W. Heegaard

      Affiliations

    • Protein Chemistry Laboratory, University of Aarhus, 8000 Aarhus C, Denmark
    • ,
  • J.T. Rasmussen

      Affiliations

    • Protein Chemistry Laboratory, University of Aarhus, 8000 Aarhus C, Denmark
    • Corresponding Author InformationCorresponding author.

Received 26 June 2006 ,Accepted 16 August 2006.

References 

  1. Arias CF, Isa P, Guerrero CA, Méndez E, Zárate S, López T, et al. Molecular biology of rotavirus cell entry. Arch. Med. Res. 2002;33:356–361
  2. Benfeldt C, Larsen LB, Rasmussen JT, Andreasen PA, Petersen TE. Isolation and characterization of plasminogen and plasmin from bovine milk. Int. Dairy J. 1995;5:577–592
  3. Burns JW, Krishnaney AA, Vo PT, Rouse RV, Anderson L, Greenberg HB. Analyses of homologous rotavirus infection in the mouse model. Virology. 1995;207:143–153
  4. European Union. Council Directive 86/609/EEC on the approximation of laws, regulations, and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. Off. J. L. 1986;358:1–28
  5. García-Díaz A, López-Andújar P, Rodríguez Díaz J, Torres Barceló C, Ribes JM, Buesa J. Nasal immunization of mice with a rotavirus DNA vaccine that induces protective intestinal IgA antibodies. Vaccine. 2004;23:489–498
  6. Gil MT, de Souza CO, Asensi M, Buesa J. Homotypic protection against rotavirus-induced diarrhea in infant mice breastfed by dams immunized with the recombinant VP8* subunit of the VP4 capsid protein. Viral Immunol. 2000;13:187–200
  7. Glass RI, Parashar UD. The promise of new rotavirus vaccines. N. Engl. J. Med. 2006;354:75–77
  8. Grover M, Giouzeppos O, Schnagl RD, May JT. Effect of human milk prostaglandins and lactoferrin on respiratory syncytial virus and rotavirus. Acta Paediatr. 1997;86:315–316
  9. Guerrero CA, Méndez E, Zárate S, Isa P, López S, Arias CF. Integrin α(v)β3 mediates rotavirus cell entry. Proc. Natl. Acad. Sci. USA. 2000;97:14644–14649
  10. Hvarregaard J, Andersen MH, Berglund L, Rasmussen JT, Petersen TE. Characterization of glycoprotein PAS-6/7 from membranes of bovine milk fat globules. Eur. J. Biochem. 1996;240:628–636
  11. Jiang B, Gentsch JR, Glass RI. The role of serum antibodies in the protection against rotavirus disease: An overview. Clin. Infect. Dis. 2002;34:1351–1361
  12. Kanamaru Y, Etoh M, Song XG, Mikogami T, Hayasawa H, Ebina T, et al. A high-Mr glycoprotein fraction from cow's milk potent in inhibiting replication of human rotavirus in vitro. Biosci. Biotechnol. Biochem. 1999;63:246–249
  13. Korhonen H, Marnila P, Gill HS. Bovine milk antibodies for health. Br. J. Nutr. 2000;84:S135–S146
  14. Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull. World Health Org. 2003;81:197–204
  15. Kvistgaard AS, Pallesen LT, Arias CF, Lopez S, Petersen TE, Heegaard CW, et al. Inhibitory effects of human and bovine milk constituents on rotavirus infections. J. Dairy Sci. 2004;87:4088–4096
  16. Lecce JG, King MW. Rotaviral antibodies in cow's milk. Can. J. Comp. Med. 1982;46:434–436
  17. McNeal MM, Belli J, Basu M, Choi AH-C, Ward RL. Discovery of a new strain of murine rotavirus that is consistently shed in large quantities after oral inoculation of adult mice. Virology. 2004;320:1–11
  18. Newburg DS, Peterson JA, Ruiz-Palacios GM, Matson DO, Morrow AL, Shults J, et al. Role of human-milk lactadherin in protection against symptomatic rotavirus infection. Lancet. 1998;351:1160–1164
  19. Pallesen LT, Andersen MH, Nielsen RL, Berglund L, Petersen TE, Rasmussen LK, et al. Purification of MUC1 from bovine milk-fat globules and characterization of a corresponding full-length cDNA clone. J. Dairy Sci. 2001;84:2591–2598
  20. Parashar UD, Gibson CJ, Bresse JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerg. Infect. Dis. 2006;12:304–306
  21. Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI. Global illness and deaths caused by rotavirus disease in children. Emerg. Infect. Dis. 2003;9:565–572
  22. Reed LF, Muench H. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 1938;27:493–497
  23. Schacterle GR, Pollack RL. A simplified method for the quantitative assay of small amounts of protein in biologic material. Anal. Biochem. 1973;51:654–655
  24. Superti F, Ammendolia MG, Valenti P, Seganti L. Antirotaviral activity of milk proteins: Lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29. Med. Microbiol. Immunol. (Berl.). 1997;186:83–91
  25. Superti F, Siciliano R, Rega B, Giansanti F, Valenti P, Antonini G. Involvement of bovine lactoferrin metal saturation, sialic acid and protein fragments in the inhibition of rotavirus infection. Biochim. Biophys. Acta. 2001;1528:107–115
  26. Ward RL, McNeal MM, Sheridan JF. Development of an adult mouse model for studies on protection against rotavirus. J. Virol. 1990;64:5070–5075
  27. Weiner C, Pan Q, Hurtig M, Boren T, Bostwick E, Hammarstrom L. Passive immunity against human pathogens using bovine antibodies. Clin. Exp. Immunol. 1999;116:193–205
  28. Wolber FM, Broomfield AM, Fray L, Cross ML, Dey D. Supplemental dietary whey protein concentrate reduces rotavirus-induced disease symptoms in suckling mice. J. Nutr. 2005;135:1470–1474
  29. Yolken RH, Losonsky GA, Vonderfecht S, Leister F, Wee SB. Antibody to human rotavirus in cow's milk. N. Engl. J. Med. 1985;312:605–610
  30. Yolken RH, Peterson JA, Vonderfecht SL, Fouts ET, Midthun K, Newburg DS. Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis. J. Clin. Invest. 1992;90:1984–1991

PII: S0022-0302(07)72609-7

doi: 10.3168/jds.S0022-0302(07)72609-7

Journal of Dairy Science
Volume 90, Issue 1 , Pages 66-74 , January 2007

Article Tools

* Image Usage & Resolution