Journal of Dairy Science
Volume 91, Issue 8 , Pages 2996-3009 , August 2008

Metabolites and Immune Variables Associated with Somatic Cell Counts of Primiparous Dairy Cows

  • A.-K. Nyman

      Affiliations

    • Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, SE-751 89 Uppsala, Sweden
    • Swedish Dairy Association, PO Box 7019, SE-750 07 Uppsala, Sweden
    • Corresponding Author InformationCorresponding author.
    • ,
  • U. Emanuelson

      Affiliations

    • Department of Clinical Sciences, Swedish University of Agricultural Sciences, PO Box 7054, SE-750 07 Uppsala, Sweden
    • ,
  • K. Holtenius

      Affiliations

    • Department of Animal Nutrition and Management, Kungsängen Research Centre, Swedish University of Agricultural Sciences, Uppsala SE-753 23, Sweden
    • ,
  • K.L. Ingvartsen

      Affiliations

    • Department of Animal Health, Welfare and Nutrition, Faculty of Agricultural Sciences, Aarhus University, PO Box 50, DK-8830 Tjele, Denmark
    • ,
  • T. Larsen

      Affiliations

    • Department of Animal Health, Welfare and Nutrition, Faculty of Agricultural Sciences, Aarhus University, PO Box 50, DK-8830 Tjele, Denmark
    • ,
  • K. Persson Waller

      Affiliations

    • Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, SE-751 89 Uppsala, Sweden
    • Department of Clinical Sciences, Swedish University of Agricultural Sciences, PO Box 7054, SE-750 07 Uppsala, Sweden

Received 21 December 2007 ,Accepted 1 May 2008.

References 

  1. Baldi A, Savoini G, Pinotti L, Monfardini E, Cheli F, Dell’Orto V. Effects of vitamin E and different energy sources on vitamin E status, milk quality and reproduction in transition cows. J. Vet. Med. A Physiol. Pathol. Clin. Med. 2000;47:599–608
  2. Bareille N, Seegers H, Kiebre-Toe MB, Beaudeau F, Fourichon C. Risk factors for elevated milk somatic cell counts during early lactation in dairy heifers. In: Proc. 10th Int. Congr. Anim. Hyg., Maastricht, the Netherlands. ADDIX, Wijk bij Duurstede, the Netherlands. 2000;p. 509–514
  3. Barkema HW, Schukken YH, Lam TJ, Beiboer ML, Wilmink H, Benedictus G, et al. Incidence of clinical mastitis in dairy herds grouped in three categories by bulk milk somatic cell counts. J. Dairy Sci. 1998;81:411–419
  4. Bouda J, Ávila J, Kawabata K, Salgado G, Doubek J. Prepartum serum concentration of free fatty acids and postpartum diseases in dairy cows. In:  Fürll M editors. Production Diseases in Farm Animals. 13th Int. Conf. Prod. Dis. Farm Anim., Leipzig, Germany. Merkur Druck und Kupier, Zentrum, Germany. 2007;p. 388
  5. Broderick GA, Clayton MK. A statistical evaluation of animal and nutritional factors influencing concentrations of milk urea nitrogen. J. Dairy Sci. 1997;80:2964–2971
  6. Burvenich C, Bannerman DD, Lippolis JD, Peelman L, Nonnecke BJ, Kehrli ME, et al. Cumulative physiological events influence the inflammatory response of the bovine udder to Escherichia coli infections during the transition period. J. Dairy Sci. 2007;90(E Suppl):E39–E54
  7. Calder PC. Fuel utilization by cells of the immune system. Proc. Nutr. Soc. 1995;54:65–82
  8. Cameron RE, Dyk PB, Herdt TH, Kaneene JB, Miller R, Bucholtz HF, et al. Dry cow diet, management, and energy balance as risk factors for displaced abomasum in high producing dairy herds. J. Dairy Sci. 1998;81:132–139
  9. Cavestany D, Blanc JE, Kulcsar M, Uriarte G, Chilibroste P, Meikle A, et al. Studies of the transition cow under a pasture-based milk production system: Metabolic profiles. J. Vet. Med. A Physiol. Pathol. Clin. Med. 2005;52:1–7
  10. Cebra CK, Heidel JR, Crisman RO, Stang BV. The relationship between endogenous cortisol, blood micronutrients, and neutrophil function in postparturient Holstein cows. J. Vet. Intern. Med. 2003;17:902–907
  11. Chilliard Y, Doreau M, Bocquier F, Lobley GE. Digestive and metabolic adaptations of ruminants to variations in food supply. In:  Journet M,  Grenet E,  Farce MH,  Thériez M,  Demarquilly C editor. Recent Developments in the Nutrition of Herbivores. Paris, France: INRA Publ; 1995;p. 329–360
  12. Dec M, Wernicki A. Conglutinin, CL-43 and CL-46-three bovine collectins. Pol. J. Vet. Sci. 2006;9:265–275
  13. Dohoo IR, Martin W, Stryhn H. Veterinary epidemiologic research. Canada: AVC Inc., Charlottetown, Prince Edward Island; 2003;
  14. French PD. Dry matter intake and blood parameters of nonlactating Holstein and Jersey cows in late gestation. J. Dairy Sci. 2006;89:1057–1061
  15. Froot KA. Consistent covariance matrix estimation with cross-sectional dependence and heteroskedasticity in financial data. J. Financ. Quant. Anal. 1989;24:333–355
  16. Grönlund U, Hulten C, Eckersall PD, Hogarth C, Waller KP. Haptoglobin and serum amyloid A in milk and serum during acute and chronic experimentally induced Staphylococcus aureus mastitis. J. Dairy Res. 2003;70:379–386
  17. Hemingway RG. The influences of dietary selenium and vitamin E intakes on milk somatic cell counts and mastitis in cows. Vet. Res. Commun. 1999;23:481–499
  18. Hogan JS, Weiss WP, Todhunter DA, Smith KL, Schoenberger PS. Bovine neutrophil responses to parenteral vitamin E. J. Dairy Sci. 1992;75:399–405
  19. Holmskov U, Jensenius JC, Tornoe I, Lovendahl P. The plasma levels of coglutinin are heritable in cattle and low levels predispose to infection. Immunology. 1998;93:431–436
  20. Ingram DG, Mitchell WR. Conglutinin levels in dairy cattle: Changes associated with parturition. Am. J. Vet. Res. 1970;31:487–492
  21. Ingram DG, Mitchell WR. Conglutinin levels in dairy cattle: Seasonal fluctuations. Am. J. Vet. Res. 1971;32:23–28
  22. Ingvartsen KL, Dewhurst RJ, Friggens NC. On the relationship between lactational performance and health: Is it yield or metabolic imbalance that cause production diseases in dairy cattle? A position paper. Livest. Prod. Sci. 2003;83:277–308
  23. Ingvartsen KL, Friggens NC. To what extent do variabilities in hormones, metabolites and energy intake explain variability in milk yield? Domest. Anim. Endocrinol. 2005;29:294–304
  24. Kehrli ME, Nonnecke BJ, Roth JA. Alterations in bovine neutrophil function during the periparturient period. Am. J. Vet. Res. 1989;50:207–214
  25. Kehrli ME, Weigel KA, Freeman AE, Thurston JR, Kelley DH. Bovine sire effects on daughters in vitro blood neutrophil functions, lymphocyte blastogenesis, serum complement and conglutinin levels. Vet. Immunol. Immunopathol. 1991;27:303–319
  26. Kommisrud E, Osteras O, Vatn T. Blood selenium associated with health and fertility in Norwegian dairy herds. Acta Vet. Scand. 2005;46:229–240
  27. Kristensen NB, Pierzynowski SG, Danfaer A. Net portal appearance of volatile fatty acids in sheep intraruminally infused with mixtures of acetate, propionate, isobutyrate, butyrate, and valerate. J. Anim. Sci. 2000;78:1372–1379
  28. Krogh-Meibom T, Holmskov U, Lovendahl P, Ingvartsen KL. A time-resolved immunofluorometric assay for quantification of collectin-43. J. Immunol. Methods. 2004;295:161–167
  29. Krogh-Meibom T, Holmskov U, Lovendahl P, Nielsen NI, Ingvartsen KL. A time-resolved immunofluorometric assay for quantification of the bovine collectin conglutinin. J. Immunol. Methods. 2004;286:87–96
  30. Littell RC, Milliken GA, Stroup WW, Wolfinger RD. SAS system for mixed models. Cary, NC: SAS Institute Inc; 1996;
  31. Løvendahl P, Purup HM. Technical note: Time-resolved fluoro-immunometric assay for intact insulin in livestock species. J. Anim. Sci. 2002;80:191–195
  32. Mallard BA, Dekkers JC, Ireland MJ, Leslie KE, Sharif S, Vankampen CL, et al. Alteration in immune responsiveness during the peripartum period and its ramification on dairy cow and calf health. J. Dairy Sci. 1998;81:585–595
  33. Mashek DG, Ingvartsen KL, Andersen JB, Vestergaard M, Larsen T. Effects of a four-day hyperinsulinemic-euglycemic clamp in early and mid-lactation dairy cows on plasma concentrations of metabolites, hormones, and binding proteins. Domest. Anim. Endocrinol. 2001;21:169–185
  34. Meglia GE, Jensen SK, Lauridsen C, Persson WK. Alpha-tocopherol concentration and stereoisomer composition in plasma and milk from dairy cows fed natural or synthetic vitamin E around calving. J. Dairy Res. 2006;73:227–234
  35. Miltenburg JD, deLange D, Crauwels APP, Bongers JH, Tielen MJM, Schukken YH, et al. Incidence of clinical mastitis in a random sample of dairy herds in the southern Netherlands. Vet. Rec. 1996;139:204–207
  36. Murata H, Shimada N, Yoshioka M. Current research on acute phase proteins in veterinary diagnosis: An overview. Vet. J. 2004;168:28–40
  37. Nyman AK, Ekman T, Emanuelson U, Gustafsson AH, Holtenius K, Waller KP, et al. Risk factors associated with the incidence of veterinary-treated clinical mastitis in Swedish dairy herds with a high milk yield and a low prevalence of subclinical mastitis. Prev. Vet. Med. 2007;78:142–160
  38. Odensten MO, Berglund B, Persson WK, Holtenius K. Metabolism and udder health at dry-off in cows of different breeds and production levels. J. Dairy Sci. 2007;90:1417–1428
  39. Odensten MO, Chilliard Y, Holtenius K. Effects of two different feeding strategies during dry-off on metabolism in high-yielding dairy cows. J. Dairy Sci. 2005;88:2072–2082
  40. Ohtsuka H, Kohiruimaki M, Hayashi T, Katsuda K, Matsuda K, Masui M, et al. Relationship between leukocyte population and nutritive conditions in dairy herds with frequently appearing mastitis. J. Vet. Med. Sci. 2006;68:113–118
  41. Persson Waller K, Hallen SC, Emanuelson U, Jensen SK. Supplementation of RRR-alpha-tocopheryl acetate to peri-parturient dairy cows in commercial herds with high mastitis incidence. J. Dairy Sci. 2007;90:3640–3646
  42. Puls R. Mineral levels in animal health: Diagnostic data. Clearbrook, Canada: Sherpa International; 1994;
  43. Rastani RR, Andrew SM, Zinn SA, Sniffen CJ. Body composition and estimated tissue energy balance in Jersey and Holstein cows during early lactation. J. Dairy Sci. 2001;84:1201–1209
  44. Reist M, Erdin D, von Euw D, Tschuemperlin K, Leuenberger H, Chilliard Y, et al. Estimation of energy balance at the individual and herd level using blood and milk traits in high-yielding dairy cows. J. Dairy Sci. 2002;85:3314–3327
  45. Rezamand P, Hoagland TA, Moyes KM, Silbart LK, Andrew SM. Energy status, lipid-soluble vitamins, and acute phase proteins in periparturient Holstein and Jersey dairy cows with or without subclinical mastitis. J. Dairy Sci. 2007;90:5097–5107
  46. Smith KL, Harrison JH, Hancock DD, Todhunter DA, Conrad HR. Effect of vitamin E and selenium supplementation on incidence of clinical mastitis and duration of clinical symptoms. J. Dairy Sci. 1984;67:1293–1300
  47. Sordillo LM, Redmond MJ, Campos M, Warren L, Babiuk LA. Cytokine activity in bovine mammary gland secretions during the periparturient period. Can. J. Vet. Res. 1991;55:298–301
  48. Suriyasathaporn W, Heuer C, Noordhuizen-Stassen EN, Schukken YH. Hyperketonemia and the impairment of udder defense: A review. Vet. Res. 2000;31:397–412
  49. Swedish Dairy Association. Animal health 2005/2006: Annual report from the animal health section. Eskilstuna, Sweden: Swedish Dairy Association; 2006;
  50. van Dam BP, Bartlett PC, Kirk JH, Mather EC. The effect of age at calving on reproduction, milk production and disease incidence in the first lactation of dairy heifers. Theriogenology. 1988;30:583–591
  51. van Knegsel ATM, van den Brand H, Dijkstra J, Tamminga S, Kemp B. Effect of dietary energy source on energy balance, production, metabolic disorders and reproduction in lactating dairy cattle. Reprod. Nutr. Dev. 2005;45:665–688
  52. Waage S, Sviland S, Odegaard SA. Identification of risk factors for clinical mastitis in dairy heifers. J. Dairy Sci. 1998;81:1275–1284
  53. Wang C, Liu JX, Yuan ZP, Wu YM, Zhai SW, Ye HW. Effect of level of metabolizable protein on milk production and nitrogen utilization in lactating dairy cows. J. Dairy Sci. 2007;90:2960–2965
  54. Wathes DC, Cheng Z, Bourne N, Taylor VJ, Coffey MP, Brotherstone S. Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. Domest. Anim. Endocrinol. 2007;33:203–225
  55. Weiss WP, Hogan JS, Smith KL, Hoblet KH. Relationships among selenium, vitamin E, and mammary gland health in commercial dairy herds. J. Dairy Sci. 1990;73:381–390

PII: S0022-0302(08)71095-6

doi: 10.3168/jds.2007-0969

Journal of Dairy Science
Volume 91, Issue 8 , Pages 2996-3009 , August 2008

Article Tools

* Image Usage & Resolution