Journal of Dairy Science
Volume 91, Issue 5 , Pages 1709-1721 , May 2008

Supramolecular Structure of the Casein Micelle

  • D.J. McMahon

      Affiliations

    • Corresponding Author InformationCorresponding author.
    • ,
  • B.S. Oommen

      Affiliations

    • Current address: Glanbia Nutritionals Research, 450 Falls Ave, Suite 255, Twin Falls, ID 83310.

Received 31 October 2007 ,Accepted 22 January 2008.

References 

  1. Bloomfield VA, Mead RJ. Structure and stability of casein micelles. J. Dairy Sci. 1975;58:592–601
  2. Dalgleish DG, Parker TG. Quantitation of αs1-casein aggregation by the use of polyfunctional models. J. Dairy Res. 1979;46:259–263
  3. Dalgleish DG, Spagnuolo PA, Goff HD. A possible structure of the casein micelle based on high-resolution scanning electron microscopy. Int. Dairy J. 2004;14:1025–1031
  4. de Kruif CG. Supra-aggregates of casein micelles as a prelude to coagulation. J. Dairy Sci. 1998;81:3019–3028
  5. de Kruif CG, Holt C. Casein micelle structure, functions, and interactions. In:  Fox PF,  McSweeney PLH editor. Advanced Dairy Chemistry—1. Proteins. Part A. New York, NY: Kluwer Academic/Plenum Publishers; 2003;p. 233–270
  6. Dickinson E, Matsumura Y. Time-dependent polymerization of β-lactoglobulin through disulfide bonds at the oil-water interface in emulsions. Int. J. Biol. Macromol. 1991;13:26–30
  7. Euston SR, Horne DS. Simulating the self-association of caseins. Food Hydrocolloids. 2005;19:379–386
  8. Farrell HM. Models for casein micelle formation. J. Dairy Sci. 1973;56:1195–1206
  9. Farrell HM, Brown EM, Hoagland PD, Malin EL. Higher order structures of caseins: A paradox. In:  Fox PF,  McSweeney P editor. Advanced Dairy Chemistry—1. Proteins. Part A. 3rd ed.. London, UK: Kluwer Academic; 2003;p. 203–232
  10. Farrell HM, Jimenez-Flores R, Bleck GT, Brown EM, Butler JE, Creamer LK, et al. Nomenclature of the proteins of cows’ milk—Sixth revision. J. Dairy Sci. 2004;87:1641–1674
  11. Farrell HM, Qi PX, Uversky VN. New views of protein structure: Applications to the caseins: Protein structure and functionality. In:  Fishman ML,  Qi PX,  Wisker L editor. Advances in Biopolymers: Molecules, Clusters, Networks, and Interactions. Washington, DC: Am. Chem. Soc; 2006;p. 52–70
  12. Heertje I, Visser J, Smits P. Structure formation in acid milk gels. Food Microstruct. 1985;4:267–278
  13. Helminen HJ, Ericsson JLE. Studies on mammary gland involution. 1. On the ultrastructure of the lactating mammary gland. J. Ultrastruct. Res. 1968;25:193–213
  14. Hojou K, Oikawa T, Kanaya K, Kimura T, Adachi K. Some applications of ion beam sputtering to high resolution electron microscopy. Micron. 1977;8:151–170
  15. Holt C, de Kruif CG, Tunier R, Timmons PA. Substructure of bovine casein micelles by small angle X-ray and neutron scattering. Colloids Surfaces A. 2003;213:275–284
  16. Holt C, Sawyer L. Caseins as rheomorphic proteins: Interpretation of the primary and secondary structures of the αs1-, β -, and κ-caseins. J. Chem. Soc., Faraday Trans. 1993;89:2683–2692
  17. Holt C, Timmins PA, Errington N, Leaver J. A core-shell model of calcium nanoclusters stabilized by β-casein phosphopeptides, derived from sedimentation equilibrium and small-angle x-ray and neutron-scattering measurements. Eur. J. Biochem. 1998;252:73–78
  18. Holt C, Wahlgren NM, Drakenberg T. Ability of a β-CN phosphopeptide to modulate the precipitation of calcium phosphate by forming amorphous dicalcium phosphate nanoclusters. Biochem. J. 1996;314:1035–1039
  19. Horne DS. Steric effects in the coagulation of casein micelles by ethanol. Biopolymers. 1984;23:989–993
  20. Horne DS. Casein interactions: Casting light on the black boxes, the structure of dairy products. Int. Dairy J. 1998;8:171–177
  21. Horne DS. Casein structure, self assembly and gelation. Curr. Opin. Colloid Interface Sci. 2002;7:456–461
  22. Horne DS, Parker TG, Dalgleish DG. Casein micelles, polycondensation, and fractals. In:  Bee RD,  Richmond P,  Mingins J editor. Food Colloids. London, UK: Royal Soc. Chem; 1988;p. 400–406
  23. International Union of Pure and Applied Chemistry. 1997. Compendium of chemical terminology. Vol. 1994, 66, 1169. 2nd ed. http://www.iupac.org/goldbook/S06153.pdf Accessed Oct. 31, 2007.
  24. Kalab M, Phipps-Todd BE, Allan-Wojtas P. Milk gel structure. 13. Rotary shadowing of casein micelles for electron microscopy. Milchwissenschaft. 1982;37:513–518
  25. Karlsson AO, Ipsen R, Ardö Y. Observations of casein micelles in skim milk concentrate by transmission electron microscopy. Food Sci. Technol. 2007;40:1102–1107
  26. Knoop AM, Knoop E, Wiechen A. Electron microscopical investigations on the structure of casein micelles. Neth. Milk Dairy J. 1973;27:121–127
  27. Lombardi L, Prenna G, Okolicsanyi L, Gautier A. Electron staining with uranyl acetate. Possible role of free amino groups. J. Histochem. Cytochem. 1971;19:161–188
  28. Malin EL, Brown EM, Wickham ED, Farrell Jr HM. Contributions of terminal peptides to the associative behavior of αs1-casein. J. Dairy Sci. 2005;88:2318–2328
  29. Marchin S, Putaux J-L, Pignon F, Léonil J. Effects of the environmental factors on the casein micelle structure studied by cryo transmission electron microscopy and small-angle x-ray scattering/ultrasmall-angle x-ray scattering. J. Chem. Phys. 2007;1–10126: art. no. 045101
  30. McMahon DJ, Brown RJ. Composition, structure, and integrity of casein micelles: A review. J. Dairy Sci. 1984;67:499–512
  31. McMahon DJ, McManus WR. Rethinking casein micelle structure using electron microscopy. J. Dairy Sci. 1998;81:2985–2993
  32. McManus WR, McMahon DJ. A new preparation technique for high resolution imaging of protein structure: Casein micelles. Microsc. Microanal. 1997;3(Suppl. 2):353–354
  33. Nermut MV. Negative staining of viruses. In:  Benedetti EL,  Favard P editor. Freeze-etching Techniques and Applications. Paris, France: Societé Française de Microscopie Électronique; 1973;p. 135–150
  34. Rasmussen LK, Johnsen LB, Tsiora A, Sørenson ES, Thomsen JK, Nielsen NC, et al. Disulphide-linked caseins and casein micelles. Int. Dairy J. 1999;9:215–218
  35. Rollema HS. Chemistry of milk proteins. In:  Fox PF editors. Developments in Dairy Chemistry—1. Proteins. London, UK: Applied Science; 1992;p. 111–140
  36. Rothstein A. A reappraisal of the action of uranyl ion on cell membranes. In:  Maniloff J,  Coleman JR,  Miller MW editor. Effects of Metals on Cells, Subcellular Elements and Macromolecules. Springfield, IL: Charles C. Thomas; 1970;p. 365–387
  37. Schmidt DG, van der Spek CA, Buchheim W, Hinz A. On the formation of artificial casein micelles. Milchwissenschaft. 1974;29:455–459
  38. Shah DO. Interaction of uranyl ions with phospholipid and cholesterol monolayer. J. Colloids Interface Sci. 1969;29:210–214
  39. Smith E, Clegg R, Holt C. A biological perspective on the structure and function of caseins and casein micelles. Int. J. Dairy Technol. 2004;57:121–126
  40. Swaisgood HE. Chemistry of the caseins. In:  Fox PF,  McSweeney PLH editor. Advanced Dairy Chemistry—1. Proteins. Part A. New York, NY: Kluwer Academic/Plenum Publishers; 2003;p. 139–187
  41. Swimme, B., and T. Berry. 1992. The Universe Story. Harper Collins, NY.
  42. Thurn A, Buchard W, Niki R. Structure of casein micelles II alpha-s1-casein. Colloid Polym. Sci. 1987;265:653–666
  43. Tziboula A, Horne DS. The role of αs1-casein in the structure of caprine casein micelles. Int. Dairy J. 1999;9:173–178
  44. Udabage P, McKinnon IR, Augustin MA. The use of sedimentation field flow fractionation and photon correlation spectroscopy in the characterization of casein micelles. J. Dairy Res. 2003;70:453–459
  45. Wang Y, Chen Y, Lavin C, Gretz MR. Extracellular matrix assembly in diatoms (Bacillariophyceae). IV. Ultrastructure of Achnanthes longipes and Cymbella cistula as revealed by high-pressure freezing/freeze substitution and cryo-field emission scanning electron microscopy. J. Phycol. 2000;36:367–378
  46. Yoshikawa M, Sasaki R, Chiba H. Effects of chemical phosphorylation of bovine casein components on the properties related to casein micelle formation. Agric. Biol. Chem. 1981;45:909–914
  47. Zobel CR, Beer M. Electron stains. I. Chemical studies on the interaction of DNA with uranyl salts. J. Biophys. Chem. Cytol. 1961;10:335–338

PII: S0022-0302(08)71207-4

doi: 10.3168/jds.2007-0819

Journal of Dairy Science
Volume 91, Issue 5 , Pages 1709-1721 , May 2008

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