Journal of Dairy Science
Volume 92, Issue 11 , Pages 5378-5385 , November 2009

Considerable variation in the concentration of osteopontin in human milk, bovine milk, and infant formulas1

  • L. Schack

      Affiliations

    • Protein Chemistry Laboratory, Department of Molecular Biology, Aarhus University, Aarhus, Denmark
    • Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark
  • ,
  • A. Lange

      Affiliations

    • Department of Pediatrics, Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark
  • ,
  • J. Kelsen

      Affiliations

    • Gastro-Immuno Research Laboratory, Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark
  • ,
  • J. Agnholt

      Affiliations

    • Gastro-Immuno Research Laboratory, Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark
  • ,
  • B. Christensen

      Affiliations

    • Protein Chemistry Laboratory, Department of Molecular Biology, Aarhus University, Aarhus, Denmark
  • ,
  • T.E. Petersen

      Affiliations

    • Protein Chemistry Laboratory, Department of Molecular Biology, Aarhus University, Aarhus, Denmark
  • ,
  • E.S. Sørensen

      Affiliations

    • Protein Chemistry Laboratory, Department of Molecular Biology, Aarhus University, Aarhus, Denmark
    • Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark
    • Corresponding Author InformationCorresponding author.

Received 7 May 2009 ,Accepted 29 July 2009.

References 

  1. Agnholt J, Kaltoft K. In situ activated intestinal T cells expanded in vitro–without addition of antigen–produce IFN-gamma and IL-10 and preserve their function during growth. Exp. Clin. Immunogenet. 2001;18:213–225
  2. Agnholt J, Kelsen J, Schack L, Hvas CL, Dahlerup JF, Sørensen ES. Osteopontin, a protein with cytokine-like properties, is associated with inflammation in Crohn's disease. Scand. J. Immunol. 2007;65:453–460
  3. Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, et al. Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity. Science. 2000;287:860–864
  4. Asplin JR, Arsenault D, Parks JH, Coe FL, Hoyer JR. Contribution of human uropontin to inhibition of calcium oxalate crystallization. Kidney Int. 1998;53:194–199
  5. Azuma N, Maeta A, Fukuchi K, Kanno C. A rapid method for purifying osteopontin from bovine milk and interaction between osteopontin and other milk proteins. Int. Dairy J. 2006;16:370–378
  6. Chatterton DEW, Rasmussen JT, Heegaard CW, Sørensen ES, Petersen TE. In vitro digestion of novel milk protein ingredients for use in infant formulas: Research on biological functions. Trends Food Sci. Technol. 2004;15:373–383
  7. Christensen B, Nielsen MS, Haselmann KF, Petersen TE, Sørensen ES. Posttranslationally modified residues of native human osteopontin are located in clusters. Identification of thirty-six phosphorylation and five O-glycosylation sites and their biological implications. Biochem. J. 2005;390:285–292
  8. Cunningham AS, Jelliffe DB, Jelliffe EF. Breast-feeding and health in the 1980s: A global epidemiologic review. J. Pediatr. 1991;118:659–666
  9. Dewey KG, Heinig MJ, Nommsen-Rivers LA. Differences in morbidity between breast-fed and formula-fed infants. J. Pediatr. 1995;126:696–702
  10. Field CJ. The immunological components of human milk and their effect on immune development in infants. J. Nutr. 2005;135:1–4
  11. Gericke A, Qin C, Spevak L, Fujimoto Y, Butler WT, Sørensen ES, et al. Importance of phosphorylation for osteopontin regulation of biomineralization. Calcif. Tissue Int. 2005;77:45–54
  12. Hambreus L, Forsum E, Lönnerdal B. Nutritional aspects of breast milk versus cow's milk formula. In:  Hambreus L,  Hanson ÅL,  McFarlane H editor. Food and Immunology, Symposia of the Swedish Nutrition Foundation. Vol. XIII:Uppsala, Sweden: Almqvist and Wiksell; 1977;p. 116–124
  13. Hanson LA, Korotkova M, Telemo E. Breast-feeding, infant formulas, and the immune system. Ann. Allergy Asthma Immunol. 2003;90:59–63
  14. Huffman SL, Combest C. Role of breast-feeding in the prevention and treatment of diarrhoea. J. Diarrhoeal Dis. Res. 1990;8:68–81
  15. Kelsen J, Agnholt J, Hoffmann HJ, Romer JL, Hvas CL, Dahlerup JF. FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease. Clin. Exp. Immunol. 2005;141:549–557
  16. Lawrence RM, Pane CA. Human breast milk: Current concepts of immunology and infectious diseases. Curr. Probl. Pediatr. Adolesc. Health Care. 2007;37:7–36
  17. Mercier JC. Phosphorylation of caseins, present evidence for an amino acid triplet code posttranslationally recognized by specific kinases. Biochimie. 1981;63:1–17
  18. Nagatomo T, Ohga S, Takada H, Nomura A, Hikino S, Imura M, et al. Microarray analysis of human milk cells: Persistent high expression of osteopontin during the lactation period. Clin. Exp. Immunol. 2004;138:47–53
  19. Nau GJ, Liaw L, Chupp GL, Berman JS, Hogan BL, Young RA. Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin. Infect. Immun. 1999;67:4223–4230
  20. Nemir M, Bhattacharyya D, Li X, Singh K, Mukherjee AB, Mukherjee BB. Targeted inhibition of osteopontin expression in the mammary gland causes abnormal morphogenesis and lactation deficiency. J. Biol. Chem. 2000;275:969–976
  21. Ohri R, Tung E, Rajachar R, Giachelli CM. Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin. Calcif. Tissue Int. 2005;76:307–315
  22. Ohshima S, Yamaguchi N, Nishioka K, Mima T, Ishii T, Umeshita-Sasai M, et al. Enhanced local production of osteopontin in rheumatoid joints. J. Rheumatol. 2002;29:2061–2067
  23. Patarca R, Freeman GJ, Singh RP, Wei FY, Durfee T, Blattner F, et al. Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J. Exp. Med. 1989;170:145–161
  24. Plumer A, Duan H, Subramaniam S, Lucas FL, Miesfeldt S, Ng AK, et al. Development of fragment-specific osteopontin antibodies and ELISA for quantification in human metastatic breast cancer. BMC Cancer. 2008;8:38–48
  25. Rittling SR, Novick KE. Osteopontin expression in mammary gland development and tumorigenesis. Cell Growth Differ. 1997;8:1061–1069
  26. Rodrigues LR, Teixeira JA, Schmitt FL, Paulsson M, Lindmark-Mansson H. The role of osteopontin in tumor progression and metastasis in breast cancer. Cancer Epidemiol. Biomarkers Prev. 2007;16:1087–1097
  27. Rollo EE, Hempson SJ, Bansal A, Tsao E, Habib I, Rittling SR, et al. The cytokine osteopontin modulates the severity of rotavirus diarrhea. J. Virol. 2005;79:3509–3516
  28. Santana MA, Rosenstein Y. What it takes to become an effector T cell: The process, the cells involved, and the mechanisms. J. Cell. Physiol. 2003;195:392–401
  29. Sato T, Nakai T, Tamura N, Okamoto S, Matsuoka K, Sakuraba A, et al. Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response. Gut. 2005;54:1254–1262
  30. Schack L, Stapulionis R, Christensen B, Kofod-Olsen E, Skov Sørensen UB, Vorup-Jensen T, et al. Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin. J. Immunol. 2009;182:6943–6950
  31. Senger DR, Perruzzi CA, Papadopoulos A, Tenen DG. Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin. Biochim. Biophys. Acta. 1989;996:43–48
  32. Sennels HP, Jacobsen S, Jensen T, Hansen MS, Ostergaard M, Nielsen HJ, et al. Biological variation and reference intervals for circulating osteopontin, osteoprotegerin, total soluble receptor activator of nuclear factor kappa B ligand and high-sensitivity C-reactive protein. Scand. J. Clin. Lab. Invest. 2007;67:821–835
  33. Sodek J, Ganss B, McKee MD. Osteopontin. Crit. Rev. Oral Biol. Med. 2000;11:279–303
  34. Sørensen ES, Højrup P, Petersen TE. Posttranslational modifications of bovine osteopontin: Identification of twenty-eight phosphorylation and three O-glycosylation sites. Protein Sci. 1995;4:2040–2049
  35. Sørensen ES, Petersen TE. Phosphorylation, glycosylation and amino acid sequence of component PP3 from the proteose peptone fraction of bovine milk. J. Dairy Res. 1993;60:535–542
  36. Sørensen ES, Petersen TE. Purification and characterization of three proteins isolated from the proteose peptone fraction of bovine milk. J. Dairy Res. 1993;60:189–197
  37. Sørensen S, Justesen SJ, Johnsen AH. Purification and characterization of osteopontin from human milk. Protein Expr. Purif. 2003;30:238–245
  38. Tomita M, Wakabayashi H, Yamauchi K, Teraguchi S, Hayasawa H. Bovine lactoferrin and lactoferricin derived from milk: Production and applications. Biochem. Cell Biol. 2002;80:109–112
  39. Vogt MH, Lopatinskaya L, Smits M, Polman CH, Nagelkerken L. Elevated osteopontin levels in active relapsing-remitting multiple sclerosis. Ann. Neurol. 2003;53:819–822
  40. Vordermark D, Said HM, Katzer A, Kuhnt T, Hansgen G, Dunst J, et al. Plasma osteopontin levels in patients with head and neck cancer and cervix cancer are critically dependent on the choice of ELISA system. BMC Cancer. 2006;6:207–212
  41. Wang KX, Denhardt DT. Osteopontin: Role in immune regulation and stress responses. Cytokine Growth Factor Rev. 2008;19:333–345

PII: S0022-0302(09)70870-7

doi: 10.3168/jds.2009-2360

Journal of Dairy Science
Volume 92, Issue 11 , Pages 5378-5385 , November 2009