Journal of Dairy Science
Volume 92, Issue 12 , Pages 5868-5882 , December 2009

A high-throughput cheese manufacturing model for effective cheese starter culture screening

  • H. Bachmann

      Affiliations

    • NIZO Food Research, PO Box 20, 6710 BA Ede, the Netherlands
    • Kluyver Centre for Genomics of Industrial Fermentation, Delft, the Netherlands
    • Vrije Universiteit Amsterdam, Systems Bioinformatics IBIVU, De Boelelaan 1085, 1081HV Amsterdam, the Netherlands
  • ,
  • Z. Kruijswijk

      Affiliations

    • NIZO Food Research, PO Box 20, 6710 BA Ede, the Netherlands
  • ,
  • D. Molenaar

      Affiliations

    • NIZO Food Research, PO Box 20, 6710 BA Ede, the Netherlands
    • Kluyver Centre for Genomics of Industrial Fermentation, Delft, the Netherlands
    • Vrije Universiteit Amsterdam, Systems Bioinformatics IBIVU, De Boelelaan 1085, 1081HV Amsterdam, the Netherlands
  • ,
  • M. Kleerebezem

      Affiliations

    • NIZO Food Research, PO Box 20, 6710 BA Ede, the Netherlands
    • Kluyver Centre for Genomics of Industrial Fermentation, Delft, the Netherlands
    • Wageningen University, Laboratory for Microbiology, Wageningen, the Netherlands
    • Corresponding Author InformationCorresponding author.
  • ,
  • J.E.T. van Hylckama Vlieg

      Affiliations

    • NIZO Food Research, PO Box 20, 6710 BA Ede, the Netherlands
    • Kluyver Centre for Genomics of Industrial Fermentation, Delft, the Netherlands
    • Danone Research, Gut and Microbiology Platform, RD 128, 91767 Palaiseau Cedex, France

Received 12 May 2009 ,Accepted 28 August 2009.

References 

  1. Ayad EHE, Verheul A, Bruinenberg P, Wouters JTM, Smit G. Starter culture development for improving the flavour of Proosdij-type cheese. Int. Dairy J. 2003;13:159–168
  2. Ayad EHE, Verheul A, Jong Cd, Wouters JTM, Smit G. Flavour forming abilities and amino acid requirements of Lactococcus lactis strains isolated from artisanal and non-dairy origin. Int. Dairy J. 1999;9:725–735
  3. Ayad EHE, Verheul A, Wouters JTM, Smit G. Application of wild starter cultures for flavour development in pilot plant cheese making. Int. Dairy J. 2000;10:169–179
  4. Ayad EHE, Verheul A, Wouters JTM, Smit G. Population dynamics of lactococci from industrial, artisanal and non-dairy origins in defined strain starters for Gouda-type cheese. Int. Dairy J. 2001;11:51–61
  5. Azarnia S, Robert N, Lee B. Biotechnological methods to accelerate cheddar cheese ripening. Crit. Rev. Biotechnol. 2006;26:121–143
  6. Bachmann H, De Wilt L, Kleerebezem M, van Hylckama Vlieg JE. Gene expression of Lactococcus lactis during the fermentation of cheese. In 9th Symposium on Lactic Acid Bacteria. the Netherlands: FEMS, Egmond aan Zee; 2008;
  7. Bachmann H, Kleerebezem M, van Hylckama Vlieg JE. High-throughput identification and validation of in situ-expressed genes of Lactococcus lactis. Appl. Environ. Microbiol. 2008;74:4727–4736
  8. Bachmann H, Starrenburg MJ, Dijkstra A, Molenaar D, Kleerebezem M, Rademaker JL, et al. Regulatory phenotyping reveals important diversity within the species Lactococcus lactis. Appl. Environ. Microbiol. 2009;75:5687–5694
  9. Biede SL, Hammond EG. Swiss cheese flavor: II. Organoleptic analysis. J. Dairy Sci. 1979;62:238–248
  10. Brandsma JB, Floris E, Dijkstra ARD, Rijnen L, Wouters JA, Meijer WC. Natural diversity of aminotransferases and dehydrogenase activity in a large collection of Lactococcus lactis strains. Int. Dairy J. 2008;18:1103–1108
  11. Breiman L. Random Forests. Mach. Learn. 2001;45:5–32
  12. Crow VL, Holland R, Pritchard GG, Coolbear T. The diversity of potential cheese ripening characteristics of lactic acid starter bacteria: 2. The levels and subcellular distributions of peptidase and esterase activities. Int. Dairy J. 1994;4:723–742
  13. El Soda M, Madkor SA, Tong PS. Adjunct cultures: Recent developments and potential significance to the cheese industry. J. Dairy Sci. 2000;83:609–619
  14. Exterkate FA, Slangen C, Siezen RJ. Effect of genetically modified Lactococcus lactis cell-envelope proteinases with altered specificity on the course of casein degradation under cheese conditions. Int. Dairy J. 2001;11:363–371
  15. Fernandez M, van Doesburg W, Rutten GA, Marugg JD, Alting AC, van Kranenburg R, et al. Molecular and functional analyses of the metC gene of Lactococcus lactis, encoding cystathionine beta-lyase. Appl. Environ. Microbiol. 2000;66:42–48
  16. Fox PF, Wallace JM. Formation of flavor compounds in cheese. Adv. Appl. Microbiol. 1997;45:17–85
  17. Fox PF, Wallace JM, Morgan S, Lynch CM, Niland EJ, Tobin J. Acceleration of cheese ripening. Antonie Van Leeuwenhoek. 1996;70:271–297
  18. Gasson MJ. Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. J. Bacteriol. 1983;154:1–9
  19. Hassan AN, Awad S, Muthukumarappan K. Effects of exopolysaccharide-producing cultures on the viscoelastic properties of reduced-fat Cheddar cheese. J. Dairy Sci. 2005;88:4221–4227
  20. Kammerlehner, J. 1989. Lab-Kaese Technologie Band III. Molkereitechnik Band 84/85. Verlag Th. Mann, Gelsenkirchen-Buer, Germany.
  21. Kuipers OP, de Ruyter PGGA, Kleerebezem M, de Vos WM. Quorum sensing-controlled gene expression in lactic acid bacteria. J. Biotechnol. 1998;64:15–21
  22. Ledeboer AM, Bezemer S, de Hiaard JJ, Schaffers IM, Verrips CT, van Vliet C, et al. Preventing phage lysis of Lactococcus lactis in cheese production using a neutralizing heavy-chain antibody fragment from llama. J. Dairy Sci. 2002;85:1376–1382
  23. Lucey JA, Johnson ME, Horne DS. Invited review: Perspectives on the basis of the rheology and texture properties of cheese. J. Dairy Sci. 2003;86:2725–2743
  24. Malo N, Hanley JA, Cerquozzi S, Pelletier J, Nadon R. Statistical practice in high-throughput screening data analysis. Nat. Biotechnol. 2006;24:167–175
  25. McSweeney PLH, José Sousa M. Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review. Lait. 2000;80:293–324
  26. Neeter R, De Jong C, Teisman HGJ, Ellen G. Determination of volatile components in cheese using dynamic headspace techniques. In:  Taylor OSMAJ editors. Flavour science: Recent developments. London: Royal Society of Chemistry; 1996;p. 293–296
  27. R-Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2008;
  28. Roginski H. Encyclopedia of Dairy Sciences. In:  Roginski H,  Fuquay JW,  Fox PF editor. Academic Press. San Diego, CA: Elsevier Science Ltd; 2003;
  29. Shakeel-Ur-Rehman , Fox PF, McSweeney PLH, Madkor SA, Farkye NY. Alternatives to pilot plant experiments in cheese-ripening studies. Int. J. Dairy Technol. 2001;54:121–126
  30. Shakeel-Ur-Rehman , McSweeney PLH, Fox PF. Protocol for the manufacture of miniature cheeses. Lait. 1998;78:607–620
  31. Simal S, Sánchez ES, Bon J, Femenia A, Rosselló C. Water and salt diffusion during cheese ripening: Effect of the external and internal resistances to mass transfer. J. Food Eng. 2001;48:269–275
  32. Smit BA, Engels WJ, Bruinsma J, van Hylckama Vlieg JE, Wouters JT, Smit G. Development of a high throughput screening method to test flavour-forming capabilities of anaerobic micro-organisms. J. Appl. Microbiol. 2004;97:306–313
  33. Smit BA, van Hylckama Vlieg JE, Engels WJ, Meijer L, Wouters JT, Smit G. Identification, cloning, and characterization of a Lactococcus lactis branched-chain alpha-keto acid decarboxylase involved in flavor formation. Appl. Environ. Microbiol. 2005;71:303–311
  34. Smit G, Smit BA, Engels WJ. Flavour formation by lactic acid bacteria and biochemical flavour profiling of cheese products. FEMS Microbiol. Rev. 2005;29:591–610
  35. van Kranenburg R, Kleerebezem M, van Hylckama Vlieg J, Ursing BM, Boekhorst J, Smit BA, et al. Flavour formation from amino acids by lactic acid bacteria: Predictions from genome sequence analysis. Int. Dairy J. 2002;12:111–121
  36. Van Slyke LL, Price WV. Cheese. New York, NY: Orange Judd Publ. Co. Inc; 1949;
  37. Visser S. Proteolytic enzymes and their relation to cheese ripening and flavor: An overview. J. Dairy Sci. 1993;76:329–350
  38. Visser S, Slangen CJ, Rollema HS. Phenotyping of bovine milk proteins by reversed-phase high-performance liquid chromatography. J. Chromatogr. A. 1991;548:361–370
  39. Yvon M, Chambellon E, Bolotin A, Roudot-Algaron F. Characterization and role of the branched-chain aminotransferase (BcaT) isolated from Lactococcus lactis subsp. cremoris NCDO 763. Appl. Environ. Microbiol. 2000;66:571–577
  40. Yvon M, Rijnen L. Cheese flavour formation by amino acid catabolism. Int. Dairy J. 2001;11:185–201
  41. Yvon M, Thirouin S, Rijnen L, Fromentier D, Gripon JC. An aminotransferase from Lactococcus lactis initiates conversion of amino acids to cheese flavor compounds. Appl. Environ. Microbiol. 1997;63:414–419

PII: S0022-0302(09)71305-0

doi: 10.3168/jds.2009-2372

Journal of Dairy Science
Volume 92, Issue 12 , Pages 5868-5882 , December 2009