Journal of Dairy Science
Volume 93, Issue 1 , Pages 19-26 , January 2010

Neutral glycosphingolipid content of ovine milk

  • L. Zancada

      Affiliations

    • Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Salamanca, 37007 Salamanca, Spain
  • ,
  • F. Sánchez-Juanes

      Affiliations

    • Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Salamanca, 37007 Salamanca, Spain
  • ,
  • J.M. Alonso

      Affiliations

    • Departamento de Bioquímica, Biología Molecular y Fisiología, Escuela Universitaria de Ingenierías Agrarias de Soria, Universidad de Valladolid, 42003 Soria, Spain
  • ,
  • P. Hueso

      Affiliations

    • Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Salamanca, 37007 Salamanca, Spain
    • Corresponding Author InformationCorresponding author.

Received 10 June 2009 ,Accepted 30 September 2009.

References 

  1. Alais C, Jollès P. Isolation, purification, and analysis of two k-casein-like fractions from sheep casein. J. Dairy Sci. 1967;50:1555–1561
  2. Anifantakis, E.M. 1986. Comparison of the physico-chemical properties of ewes’ and cows’ milk. Pages 42–53 in IDF Bulletin no. 202 International Dairy Federation, Brussels, Belgium.
  3. Bock K, Breimer ME, Brignole A, Hansson GC, Karlsson KA, Larson G, et al. Specificity of binding of a strain of uropathogenic Escherichia coli to Gal α1–4Gal-containing glycosphingolipids. J. Biol. Chem. 1985;260:8545–8551
  4. Christie WW, Noble RC, Davies G. Phospholipids in milk and dairy products. J. Soc. Dairy Technol. 1987;40:10–12
  5. Dai D, Walker WA. Protective nutrients and bacterial colonization in the immature human gut. Adv. Pediatr. 1999;46:353–382
  6. Dewettinck K, Rombaut R, Thienpont N, Le TT, Messens K, Van Camp J. Nutritional and technological aspects of milk fat globule membrane material. Int. Dairy J. 2008;18:436–457
  7. Dasgupta S, Hogan EL, Spicer SS. Stage-specific expression of fuco-neolacto- (Lewis X) and ganglio-series neutral glycosphingolipids during brain development: Characterization of Lewis X and related glycosphingolipids in bovine, human and rat brain. Glycoconj. J. 1996;13:367–375
  8. Evans DG, Evans DJ. New surface-associated heat-labile colonization factor antigen (CFA/II) produced by enterotoxigenic Escherichia coli of serogroups O6 and O8. Infect. Immun. 1978;21:638–647
  9. Fauquant C, Briard V, Leconte N, Michalski MC. Differently sized native milk fat globules separated by microfiltration: Fatty acid composition of the milk fat globule membrane and triglyceride core. Eur. J. Lipid Sci. Technol. 2005;107:80–86
  10. Fauquant C, Briard-Brion V, Leconte N, Guichardant M, Michalski MC. Membrane phospholipids and sterols in microfiltered milk fat globules. Eur. J. Lipid Sci. Technol. 2007;109:1167–1173
  11. Graves ELF, Beaulieu AD, Drackley JD. Factors affecting the concentration of sphingomyelin in bovine milk. J. Dairy Sci. 2007;90:706–715
  12. Guineé PA, Veldkamp J, Jansen WH. Improved Minca medium for the detection of K99 antigen in calf enterotoxigenic strains of Escherichia coli. Infect. Immun. 1977;15:676–678
  13. IDF. 1996. Provisional standard 1D. Milk determination of fat content. Gravimetric method (reference method). International Dairy Federation, Brussels, Belgium.
  14. Isaacs CE. Human milk inactivates pathogens individually, additively, and synergistically. J. Nutr. 2005;135:1286–1288
  15. Karlsson KA. Animal glycosphingolipid as membrane attachment sites for bacteria. Annu. Rev. Biochem. 1989;58:309–350
  16. Karlsson KA, Stromberg N. Overlay and solid-phase analysis of glycolipid receptors for bacteria and viruses. Methods Enzymol. 1987;138:220–232
  17. Keenan TW, Patton S. Nature of the milk lipid globule membrane. In:  Jensen RG editors. Handbook of Milk Composition. New York, NY: Academic Press Inc.; 1995;p. 5–20
  18. Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenzinger JN. Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of α1–4-glycosyltransferases conserved in plants, insects and mammals. J. Biol. Chem. 2000;275:25315–25321
  19. Kiarash A, Boyd B, Lingwood CA. Glycosphingolipid receptor function is modified by fatty acid content. J. Biol. Chem. 1994;269:11138–11146
  20. Martín MJ, Martín-Sosa S, Alonso JM, Hueso P. Enterotoxigenic Escherichia coli strains bind bovine milk gangliosides in a ceramide-dependent process. Lipids. 2003;38:761–768
  21. Martín MJ, Martín-Sosa S, Hueso P. Bovine milk gangliosides: Changes in ceramide moiety with stage of lactation. Lipids. 2001;36:291–298
  22. Morrisey PA. The N-acetyl neuraminic acid content of the milk of various species. J. Dairy Res. 1973;40:421–425
  23. Morrison WR, Jack EL, Smith LM. Fatty acids of bovine milk glycolipids and phospholipids and their specific distribution in diacylglycerophospholipids. J. Am. Oil Chem. Soc. 1965;42:1142–1147
  24. Newburg DS. Oligosaccharides and glycoconjugates in human milk: Their role in host defense. J. Mammary Gland Biol. Neoplasia. 1996;1:271–283
  25. Newburg DS. Innate immunity and human milk. J. Nutr. 2005;135:1308–1312
  26. Newburg DS, Ashkenazi S, Cleary TG. Human milk contains the Shiga toxin and Shiga-like toxin receptor glycolipid Gb3. J. Infect. Dis. 1992;166:832–836
  27. Newburg DS, Chaturvedi P. Neutral glycolipids of human and bovine milk. Lipids. 1992;27:923–927
  28. Newburg DS, Ruiz-Palacios GM, Morrow AL. Human milk glycans protect infants against enteric pathogens. Annu. Rev. Nutr. 2005;25:37–58
  29. Puente R, García-Pardo LA, Rueda R, Gil A, Hueso P. Ewes’ milk: Changes in the contents of gangliosides and sialic acid during lactation. J. Dairy Res. 1995;62:651–654
  30. Rosengren B, Manson JE, Svennerholm L. Composition of gangliosides and neutral glycosphingolipids of brain in classical Tay-Sachs and Sandhoff disease: More lyso-GM2 in Sandhoff disease?. J. Neurochem. 1987;49:834–840
  31. Rueda R. The role of dietary gangliosides on immunity and the prevention of infection. Br. J. Nutr. 2007;98:568–573
  32. Sánchez-Juanes F, Alonso JM, Zancada L, Hueso P. Glycosphingolipids from bovine milk and milk fat globule membranes: A comparative study. Adhesion to enterotoxigenic Escherichia coli strains. Biol. Chem. 2009;390:31–40
  33. Schweppe CH, Bielaszewska M, Pohlentz G, Friedrich AW, Büntemeyer H, Schmidt MA, et al. Glycosphingolipids in vascular endothelial cells: Relationship of heterogeneity in Gb3/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity. Glycoconj. J. 2008;25:291–304
  34. Sonnino S, Prinetti A, Nakayama H, Yangida M, Ogawa I, Iwabuchi K. Role of very long chain fatty acid-containing glycosphingolipids in membrane organization and cell signalling: The model of lactosylceramide in neutrophils. Glycoconj. J. 2009;26:615–621
  35. Teneberg S, Willemsen PTJ, de Graaf FK, Stenhagen G, Pimlott W, Jovall PA, et al. Characterization of gangliosides of epithelial cells of calf small intestine with special reference to receptor-active sequences for enterophatogenic Escherichia coli K99. J. Biochem. 1994;116:560–574
  36. Vesper H, Schmelz EM, Nikolova-Karakashian MN, Dillehay DL, Lynch DV, Merrill AH. Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J. Nutr. 1999;129:1239–1250
  37. Zaas DW, Duncan M, Wright JR, Abraham SN. The role of lipid rafts in the pathogenesis of bacterial infections. Biochim. Biophys. Acta. 2005;1746:305–313

PII: S0022-0302(10)70260-5

doi: 10.3168/jds.2009-2476

Journal of Dairy Science
Volume 93, Issue 1 , Pages 19-26 , January 2010