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Research-Article| Volume 72, ISSUE 3, P642-651, March 1989

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Long-Term Evaluation of a Prolonged-Release Formulation of N-Methionyl Bovine Somatotropin in Lactating Dairy Cows1,2

  • Dale E. Bauman
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Author Footnotes
    3 Monsanto Company.
    Douglas L. Hard
    Footnotes
    3 Monsanto Company.
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Author Footnotes
    4 Present address: 130 Haecker Hall, Department of Animal Science, University of Minnesota, St. Paul, MN 55108.
    Brian A. Crooker
    Footnotes
    4 Present address: 130 Haecker Hall, Department of Animal Science, University of Minnesota, St. Paul, MN 55108.
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Mary S. Partridge
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Karen Garrick
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Leslie D. Sandles
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Hollis N. Erb
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Author Footnotes
    3 Monsanto Company.
    S.E. Franson
    Footnotes
    3 Monsanto Company.
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Author Footnotes
    3 Monsanto Company.
    Gary F. Hartnell
    Footnotes
    3 Monsanto Company.
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Author Footnotes
    3 Monsanto Company.
    R.L. Hintz
    Footnotes
    3 Monsanto Company.
    Affiliations
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801 and Monsanto Agricultural Company, Animal Sciences Division, St. Louis, MO 63198
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  • Author Footnotes
    1 Support in part by Cornell University Agricultural Experiment Station, USDA (Hatch 127-447), and Monsanto Agricultural Company.
    2 Authors gratefully acknowledge the assistance of staff at the Cornell University Dairy Teaching and Research Unit and Monsanto Company.
    3 Monsanto Company.
    4 Present address: 130 Haecker Hall, Department of Animal Science, University of Minnesota, St. Paul, MN 55108.
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      Abstract

      Eighty Holstein cows (first, second, or third lactation) were used to evaluate the efficacy of a prolonged-release formulation for sometribove (n-methionyl bovine somatotropin). Cows were fed ad libitum a complete mixed diet and milked twice daily. Cows were allocated randomly by parity to two treatment groups receiving 500 mg sometribove in a prolonged release formulation or excipient at 14-d intervals starting at 60 ± 3 d postpartum and continuing for 36 wk. Treatment with sometribove increased FCM yield to a similar extent (11.4%, +3.1 kg/d) in primiparous and multiparous animals. Milk content of lactose, fat, ash, and Ca was not affected, but protein and phosphorous were slightly greater (<5%) in milk from sometribove-treated cows. Within a 14-d injection interval, animals treated with sometribove displayed a cyclic pattern in milk yield, but a similar pattern was not evident in feed intake. Protein and fat percentages in milk were higher the 2nd wk of the injection cycle (6 and 4%, respectively) and this difference appears unrelated to nutrient balance. Over the treatment period (252 d), sometribove-treated animals increased voluntary feed intake to a sufficient extent so that body weight gains, net energy balance, and body condition scores did not differ between treatment groups. Gross lactational efficiency (milk per unit of feed) was improved in sometribove-treated cows, and no adverse health effects were observed. Results demonstrate that bovine somatotropin administered by a prolonged-release formulation is effective in improving milk yield and productive efficiency.

      References

        • Asimov G.J.
        • Krouze N.K.
        The lacto genic preparations from the anterior pituitary and the increase of milk yield in cows.
        J. Dairy Sci. 1937; 20: 289
        • Association of Official Analytical Chemists
        Official methods of analysis.
        13th ed. Assoc. Offic. Anal. Chem., Washington, DC1980
        • Bauman D.E.
        • Currie W.B.
        Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis.
        J. Dairy Sci. 1980; 63: 1514
        • Bauman D.E.
        • Eppard P.J.
        • DeGeeter M.J.
        • Lanza G.M.
        Responses of high-producing dairy cows to long-term treatment with pituitary somatotropin and recombinant somatotropin.
        J. Dairy Sci. 1985; 68: 1352
        • Bauman D.E.
        • McCutcheon S.N.
        The effects of growth hormone and prolactin on metabolism.
        in: Milligan L.P. Grovum W.L. Dobson A. Control of digestion and metabolism in ruminants. Prentice-Hall, Englewood Cliffs, NJ1986: 436-455
        • Bauman D.E.
        • Peel C.J.
        • Steinhour W.D.
        • Reynolds P.J.
        • Tyrrell H.F.
        • Brown A.C.G.
        • Haaland G.L.
        Effect of bovine somatotropin on metabolism of lactating dairy cows: influence on rates of irreversible loss and oxidation of glucose and nonesterified fatty acids.
        J. Nutr. 1988; 118: 1031
        • Bines J.A.
        • Hart I.C.
        • Morant S.V.
        Endocrine control of energy metabolism in the cow: the effect on milk yield and levels of some blood constituents of injecting growth hormone and growth hormone fragments.
        Br. J. Nutr. 1980; 43: 179
        • Boyd R.D.
        • Bauman D.E.
        Mechanisms of action for somatotropin in growth.
        in: Campion D.R. Hausman G.J. Martin R.J. Animal growth regulation. Plenum Press, New York, NY1989: 257-293
        • Brumby P.J.
        • Hancock J.
        The galacto poietic role of growth hormone in dairy cattle.
        N.Z. J. Sci. Technol. 1955; 36A: 417
        • Cotes P.M.
        • Crichton J.A.
        • Foley S.J.
        • Young F.G.
        Galactopoietic activity of purified anterior pituitary growth hormone.
        Nature. 1949; 164: 992
        • Eppard P.J.
        • Bauman D.E.
        • Curtis C.R.
        • Erb H.N.
        • Lanza G.M.
        • DeGeeter M.J.
        Effect of 188-day treatment with somatotropin on health and reproductive performance of lactating dairy cows.
        J. Dairy Sci. 1987; 70: 582
        • Eppard P.J.
        • Bauman D.E.
        • McCutcheon S.N.
        Effect of dose of bovine growth hormone on lactational performance of dairy cows.
        J. Dairy Sci. 1985; 68: 1109
        • Fronk T.J.
        • Peel C.J.
        • Bauman D.E.
        • Gorewit R.C.
        Comparison of different patterns of exogenous growth hormone administration on milk production in Holstein cows.
        J. Anim. Sci. 1983; 57: 699
      1. Griffiths M.C. USAN and the USP dictionary of drug names. United States Pharma copeial Conv., Inc., Rockville, MD1987
        • Johnsson I.D.
        • Hart I.C.
        Manipulation of milk yield with growth hormone.
        in: Haresign W. Cole D.J.A. Recent advances in animal nutrition, 20th Nutr. Conf. Feed Manuf. Butterworths, London, Engl1986: 105-123
        • Kronfeld D.S.
        Major metabolic determinants of milk volume, mammary efficiency and spontaneous ketosis in dairy cows.
        J. Dairy Sci. 1982; 65: 2204
        • Machlin L.J.
        Effect of growth hormone on milk production and feed utilization in dairy cows.
        J. Dairy Sci. 1973; 56: 575
        • McCutcheon S.N.
        • Bauman D.E.
        Effect of pattern of administration of bovine growth hormone on lactational performance of dairy cows.
        J. Dairy Sci. 1986; 69: 38
      2. National Research Council. 1978. Nutrient requirements of domestic animals. No. 3. Nutrient requirements of dairy cattle. 5th rev. ed. Natl. Acad. Sci., Washington, DC.

        • Peel C.J.
        • Bauman D.E.
        Somatotropin and lactation.
        J. Dairy Sci. 1987; 70: 474
        • Peel C.J.
        • Bauman D.E.
        • Gorewit R.C.
        • Sniffen C.J.
        Effect of exogenous growth hormone on lactational performance in high yielding dairy cows.
        J. Nutr. 1981; 111: 1662
        • Peel C.J.
        • Sandles L.D.
        • Quelch K.J.
        • Herington A.C.
        The effects of long-term administration of bovine growth hormone on the lactational performance of identical-twin dairy cows.
        Anim. Prod. 1985; 41: 135
        • Sechen S.J.
        • Bauman D.E.
        • Tyrrell H.F.
        • Reynolds P.J.
        Effect of somatotropin on kinetics of nonesterified fatty acids and partition of energy, carbon, and nitrogen in lactating dairy cows.
        J. Dairy Sci. 1989; 72: 59
        • Soderholm C.G.
        • Otterby D.E.
        • Linn J.G.
        • Ehle F.R.
        • Wheaton J.E.
        • Hansen W.P.
        • Annexstad R.J.
        Effects of recombinant bovine somatotropin on milk production, body composition, and physiological parameters.
        J. Dairy Sci. 1988; 71: 355
      3. Statistical Analysis System. 1982 SAS User's guide: statistics. SAS Inst. Cary, NC.

        • Tyrrell H.F.
        • Brown A.C.G.
        • Reynolds P.J.
        • Haaland G.L.
        • Bauman D.E.
        • Peel C.J.
        • Steinhour W.D.
        Effect of bovine somatotropin on metabolism of lactating dairy cows: energy and nitrogen utilization as determined by respiration calorimetry.
        J. Nutr. 1988; 118: 1024
        • Wildman E.E.
        • Jones G.M.
        • Wagner P.E.
        • Boman R.L.
        • Troutt Jr., H.F.
        • Lesch T.N.
        A dairy cow body condition scoring system and its relationship to selected production characteristics.
        J. Dairy Sci. 1982; 65: 495
        • Young F.G.
        Experimental stimulation (galactopoiesis) of lactation.
        Br. Med. Bull. 1947; 5: 155
        • Young IV, F.G.
        Growth hormone and metabolism: the growth hormone and diabetes.
        Recent Prog. Horm. Res. 1953; 8: 471