Advertisement
Article| Volume 74, ISSUE 4, P1263-1276, April 1991

Download started.

Ok

Effect of Somidobove Sustained Release Administration on the Lactation Performance of Dairy Cows

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Lactation performance was determined on 190 multiparous Holsteins from five herds supplemented with 0, 320, 640, or 960 mg of somidobove every 28 d. The experiment consisted of 21 d of pretreatment and treatment periods of various lengths, depending upon stage of lactation of animals at first administration. Somidobove beginning in early (28 to 45 d in milk), mid (111 to 166 d in milk), or late (166 to 334 d in milk) stages of lactation consisted of 9, 6, or 3 administrations. Milk and 3.5% FCM yields were increased by each dose of somidobove in all stages. Milk composition and dry matter and energy intakes were similar among treatments within stage. Milk to DMI ratio and milk energy to net energy intake ratio were improved by somidobove. Gain was positive for all treatments, but less in somidobove-supplemented cows. Lower body weight and condition score at the completion of somidobove treatment resulted. For early cows, days to first estrus and days to first breeding were similar, however, total number of inseminations for cows receiving somidobove was twofold greater than control, resulting in a longer calving interval. Results demonstrated efficacy of somidobove administered every 28 d to lactating dairy cattle for increased milk yield.

      Key words

      Abbreviation Key:

      NADA (new animal drug application), NEI (net energy intake), PP (postpartum)

      References

        • Association of Official Analytical Chemists
        Official methods of analysis.
        13th ed. AOAC, Washington, DC1980
        • Bauman D.E.
        • Eppard P.J.
        • DeGeeter M.J.
        • Lanza G.M.
        Responses of high producing dairy cows to long-term treatment with pituitaiy somatotropin and recombinant somatotropin.
        J. Dairy Sci. 1985; 68: 1352
        • Bauman D.E.
        • Hard D.L.
        • Crooker B.A.
        • Partridge M.S.
        • Garrick K.
        • Sandles L.D.
        • Erb H.N.
        • Franson S.E.
        • Hartnell G.F.
        • Hintz R.L.
        Longterr evaluation of a prolonged-release formulation of n-methionyl bovine somatotropin in lactating dairy cows.
        J. Dairy Sci. 1989; 72: 642
        • Broster W.H.
        • Broster V.J.
        • Smith T.
        • Siviter I.W.
        Experiments on the nutrition of the dairy heifer. IX. Food utilization in lactation.
        J. Agric. Sci. (Camb.). 1975; 84: 173
        • Chalupa W.
        • Baird L.
        • Soderholm C.
        • Palmquist D.L.
        • Hemken R.
        • Otterby D.
        • Annexstad R.
        • Vecchiarelli B.
        • Harmon R.
        • Sinha A.
        • Linn J.
        • Hansen W.
        • Ehle F.
        • Schneider P.
        • Eggert R.
        Responses of dairy cows to somatotropin.
        J. Dairy Sci. 1987; 70 (Abstr.): 176
        • Chalupa W.
        • Galligan D.T.
        Nutritional implications of somatotropin for lactating cows.
        J. Dairy Sci. 1989; 72: 2510
        • Chalupa W.
        • Kutches A.
        • Swager D.
        • Lehenbauer T.
        • Vecchiarelli B.
        • Shaver R.
        • Robb E.
        Responses of cows in a commercial dairy to somatotropin.
        J. Dairy Sci. 1988; 71 (Abstr.): 210
      1. Code of Federal Regulations. 1987. Food and drugs. 21:514(8). Natl. Archiv. Records Admin., US Govt. Printing Office, Washington, DC.

        • Eppard P.J.
        • Bauman D.E.
        • Curtis C.R.
        • Erb H.N.
        • Lanza G.M.
        • DeGeeter M.J.
        Effect of 188 day treatment with somatotropin on health and reproductive performance of lactating dairy cows.
        J. Dairy Sci. 1987; 70: 582
        • Gill J.L.
        Design and analysis of experiments in the animal and medical sciences.
        The Iowa State Univ. Press, Ames1978
        • Hard D.L.
        • Cole W.J.
        • Franson S.E.
        • Samuels W.A.
        • Bauman D.E.
        • Erb H.N.
        • Huber J.T.
        • Lamb R.C.
        Effect of long-term sometribove, USAN (recombinant methionyl bovine somatotropin), treatment in a prolonged release system on milk yield, animal health and reproductive performance pooled across four sites.
        J. Dairy Sci. 1988; 71 (Abstr.): 210
        • Herrler A.
        • Farries E.
        • Niemann H.
        A trial to stimulate insulin-like growth factor I levels to improve superovulatory response in dairy cows.
        Theriogenology. 1990; 33 (Abstr.): 248
        • McGuffey R.K.
        • Green H.B.
        • Basson R.P.
        • Ferguson T.H.
        Lactation response of dairy cows receiving bovine somatotropin via daily injections or in a sustained release vehicle.
        J. Dairy Sci. 1990; 73: 763
        • McGuffey R.K.
        • Wilkinson J.I.D.
        Nutritional implications of bovine somatotropin for the lactating dairy cow.
        J. Dairy Sci. 1991; 74: 63
      2. Mulvaney, P. 1977. Dairy cattle condition scoring. National Institute for Research in Dairying. Paper No. 4468. Shinfield, Reading, Berkshire, Engl.

        • National Research Council
        Nutrient requirements of dairy cattle.
        5th ed. Natl. Acad. Sci., Washington, DC1978
        • Peel C.J.
        • Bauman D.E.
        Somatotropin and lactation.
        J. Dairy Sci. 1987; 70: 474
        • Phipps R.H.
        A review of the influence of somatotropin on health, reproduction and welfare in lactating dairy cows.
        in: Sjersen K. Vestergaard M. Nieman-Sorensen A. Uses of somatotropin in livestock production. Elsevier Applied Science, London, Engl.1989: 88
      3. SAS® User's Guide: Statistics, Version 82.3. SAS Inst, Inc., Cary, NC.

        • Schams D.
        Somatotropin and related peptides in milk.
        in: Sjersen K. Vestergaard M. Nieman-Sorensen A. Uses of somatotropin in livestock production. Elsevier Applied Science, London, Engl.1989: 192
        • Soderholm C.G.
        • Otterby D.E.
        • Linn J.G.
        • Ehle F.E.
        • Wheaton J.E.
        • Hansen W.P.
        • Annexstad R.J.
        Effects of different doses of recombinant bovine somatotropin on milk production, body composition, and physiological parameters.
        J. Dairy Sci. 1988; 71: 355
        • Tyrrell H.F.
        • Reid J.T.
        Prediction of the energy value of cow's milk.
        J. Dairy Sci. 1965; 48: 1215
        • Wilkinson J.I.D.
        • McGuffey R.K.
        Recent developments in somatotropin research.
        in: 4th Int Symp. Modern Cattle Prod. German Cattle Breeders Assoc., Giessen, Germany1989