This paper is only available as a PDF. To read, Please Download here.
Abstract
Animal feed additives have for many years constituted the largest and most controversial category of antimicrobial use. The primary concerns addressed have been the generation of antibiotic resistance in animal bacteria and the influence of such resistance on human health. Studies designed to shed light on the controversy generally have yielded information leading to ambiguous conclusions. A 1989 report from the National Academy of Sciences was the latest of a long collection of assessments that have been meant to provide expert guidance to regulatory authorities on this matter. The FDA has been trying for some time to determine whether a regulatory decision on existing products is warranted. After several decades of research directed at this question, most qualified study groups have reported a paucity of appropriate information necessary to judge the reality of a public health risk.
Key words
Abbreviation key:
CDC (Centers for Disease Control), CVM (Center for Veterinary Medicine), NAS (National Academy of Sciences)References
- Antimicrobial agent susceptibility patterns of bacteria in hospitals from 1971–1982.J. Clin. Microbiol. 1984; 20: 791
- Drag-resistant Salmonella from animals fed antimicrobials.New England J. Med. 1984; 311: 617
- Animal-to-man transmission of antimicrobial-resistant Salmonella: investigations of U.S. Outbreaks, 1971–1983.Science. 1984; 225: 833
- Committee on Human Health Risk Assessment of Using Subtherapevtic Antibiotics in Animal Feed. Human Health Risks with the Submerapeutic Use of Penicillin or Tetracyclines in Animal Feed.Natl. Acad. Press, Washington, DC1989
- Antibiotic resistance in pigs following a 13-year ban.J. Anim. Sci. 1986; 62: 18
- Antibiotic resistance of fecal conforms from swine fed subtherapeutic and therapeutic levels of chlortetracycline.J. Anim. Sci. 1984; 58: 666
- Salmonellae susceptibility patterns in hospitals from 1975 through 1984.J. Clin. Microbiol. 1986; 23: 826
- Committee on The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds. Effects on Human Health of Submerapeutic Use of Antimicrobials in Animal Feeds.Natl. Acad. Press, Washington, DC1980
Netherthorpe. 1962. Report of the Joint Committee on Antibiotics in Animal Feeding. Agric. Res. Counc. Med. Res. Counc., London, Engl.
O’Brien, T. F. and the Members of Task Force 2. 1987. Resistance of bacteria to antibacterial agents: Report of Task Force 2. Rev. Infect Dis. 9(Suppl. 3):S244.
- Chloramphenicol-resistant Salmonella newport traced through hamburger to dairy farms.New England. J. Med. 1987; 316: 565
- The National Resources Defense Council, Inc. submission of a petition to die Secretary of Health and Human Services.Fed. Reg. 1984; 49: 49645
- Joint Committee on the Use of Antibiotics in Animal Husbandry and Veterinary Medicine.Her Majesty's Stationery Office, London, Engl1969
Article info
Publication history
Accepted:
January 29,
1990
Received:
September 28,
1989
Identification
Copyright
© 1991 American Dairy Science Association. Published by Elsevier Inc.
User license
Elsevier user license | How you can reuse
Elsevier's open access license policy

Elsevier user license
Permitted
For non-commercial purposes:
- Read, print & download
- Text & data mine
- Translate the article
Not Permitted
- Reuse portions or extracts from the article in other works
- Redistribute or republish the final article
- Sell or re-use for commercial purposes
Elsevier's open access license policy