Article| Volume 75, ISSUE 4, P976-981, April 1992

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Antimutagenicity of Milk Cultured with Lactic Acid Bacteria Against N-Methyl-N’-Nitro-N-Nitrosoguanidine

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      The antimutagenic effect of cultured milk using 71 strains of lactic acid bacteria belonging to the genus Lactobacillus, Streptococcus, Lactococcus, and Bifidobacterium on the mutagenicity of N-methyl-N’-nitro-N-nitrosoguanidine was investigated in vitro using Salmonella typhimurium TA 100 as an indicator bacterium. Each cultwed milk sample displayed its characteristic antimutagenic effect on the mutagenicity of N-methyl-N’-nitro-N-nitrosoguanidine. The milk cultured with Lactobacillus acidophilus LA 106 (LA2) showed the highest inhibition of 77% against the mutagenicity of N-methyl-N’-nitro-N-nitrosoguanidine among the strains tested. Changes in the antimutagenic effect of the milk cultured by Lb. acidophilus LA 106 (LA2) during incubation were also examined using N-methyl-N’-nitro-N-nitrosoguanidine as a mutagen.

      Key words

      Abbreviation key:

      MNNG (N-methyl-N’-nitro-N-nitrosoguanidine), Trp-P-1 (3-amino-1 4-dimethyl-5H-pyrido[4,3-b]indole), Trp-P-2 (3-ammo-l-methyl-5H-pyrido[4,3-b]indole)


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