This paper is only available as a PDF. To read, Please Download here.
Abstract
The antimutagenic effect of cultured milk using 71 strains of lactic acid bacteria belonging to the genus Lactobacillus, Streptococcus, Lactococcus, and Bifidobacterium on the mutagenicity of N-methyl-N’-nitro-N-nitrosoguanidine was investigated in vitro using Salmonella typhimurium TA 100 as an indicator bacterium. Each cultwed milk sample displayed its characteristic antimutagenic effect on the mutagenicity of N-methyl-N’-nitro-N-nitrosoguanidine. The milk cultured with Lactobacillus acidophilus LA 106 (LA2) showed the highest inhibition of 77% against the mutagenicity of N-methyl-N’-nitro-N-nitrosoguanidine among the strains tested. Changes in the antimutagenic effect of the milk cultured by Lb. acidophilus LA 106 (LA2) during incubation were also examined using N-methyl-N’-nitro-N-nitrosoguanidine as a mutagen.
Key words
Abbreviation key:
MNNG (N-methyl-N’-nitro-N-nitrosoguanidine), Trp-P-1 (3-amino-1 4-dimethyl-5H-pyrido[4,3-b]indole), Trp-P-2 (3-ammo-l-methyl-5H-pyrido[4,3-b]indole)References
- Antitumor components of yogurt: fractionation.J. Dairy Sci. 1981; 64: 2318
- Anticarcinogenic and immunological properties of dietary lactobacilli.J. Food Prot. 1990; 53: 704
- Health and nutritional benefits from lactic acid bacteria.Fed. Eur. Microbiol. Soc. Microbiol. Rev. 1990; 87: 175
- The role of diet in the causation and prevention of cancer.in: Chandan R.C. Yogurt: nutritional and health properties. Natl. Yogurt Assoc., McLean, VA1989: 225
- Inhibition by L-ascorbate of bacterial mutagenesis induced by two N-nitroso compounds.Nature (Lond.). 1977; 268: 368
- Antimutagenic properties of lactic acid-cultured milk on chemical and fecal mutagens.J. Dairy Sci. 1986; 69: 2237
- Desmuta-genic effect of cultured milk on chemically induced mutagenesis in Escherichia coli B/r WP2 trp- hcr-.Milchwissenschaft. 1986; 41: 142
- Antimutagenic activity of whole casein on the pepper-induced mutagenicity to streptomycin-dependent strain SD 510 of Salmonella typhimurium TA 98.J. Dairy Res. 1988; 55: 435
- Binding properties of lactic acid bacteria from kefir milk with mutagenic amino acid pyrolyzates.Milchwissenschaft. 1990; 45: 647
- Inhibitory effect of lactic acid bacteria from fermented milk on the mutagenicities of volatile nitrosoamines.Agric. Biol. Chem. 1990; 54: 1639
- Des-mutagenic property of cell walls of Streptococcus faecalis on the mutagenicities induced by amino acid pyrolyzates.Milchwissenschaft. 1988; 43: 168
- A new chemical mutagen for bacteria, l-methyl-3-nitro-1-nitrosoguanidine.Biochem. Biophys. Res. Commun. 1960; 3: 575
- A novel phosphopolysaccharide from slime-forming Lactococcus lactis subspecies cremoris SBT 0495.J. Dairy Sci. 1990; 73: 1472
- Yogurt—its nutritional and health benefits.Dairy Counc. Dig. 1990; 61: 1
- Inhibitors of mutagenesis and their relevance to carcinogenesis.Mutat. Res. 1986; 168: 47
- Antitumor activity of yogurt components.J. Food Prot. 1983; 46: 8
- Antimutagenicity profiles for some model compounds.Mutat Res. 1990; 238: 57
Article info
Publication history
Accepted:
November 12,
1991
Received:
August 2,
1991
Identification
Copyright
© 1992 American Dairy Science Association. Published by Elsevier Inc.
User license
Elsevier user license | How you can reuse 
Elsevier's open access license policy
Elsevier user license
Permitted
For non-commercial purposes:
- Read, print & download
- Text & data mine
- Translate the article
Not Permitted
- Reuse portions or extracts from the article in other works
- Redistribute or republish the final article
- Sell or re-use for commercial purposes
Elsevier's open access license policy
