This paper is only available as a PDF. To read, Please Download here.
Abstract
A vaccine against bovine mastitis was developed. The vaccine was based on inactivated, highly encapsulated Staphylococcus aureus cells; a crude extract of Staph. aureus exopolysaccharides; and inactivated unencapsulated Staph. aureus and Streptococcus spp. cells. In this study, the vaccine was evaluated in 164 cows from two commercial dairies (A and B) during a 4-mo period. Two doses of the vaccine were administered subcutaneously to 82 cows in the brachiocephalicus muscle of the neck within a 4-wk interval. The results of this trial revealed significantly fewer intramammary infections caused by Staph. aureus at various levels of severity (clinical, subclinical, and latent) in cows that were vaccinated. The odds ratios of all types of intramammary infections caused by Staph. aureus for dairies A and B, which were determined by a logistic model, were 1.84 and 1.89, respectively, for quarters of vaccinated cows and quarters of control cows. The colony counts for Staph. aureus in milk from infected quarters of vaccinated cows were significantly lower than those in milk from infected quarters of control cows. Also, the somatic cell counts per milliliter in milk from vaccinated cows were significantly decreased when the initial somatic cell count was <500,000 cells/ml at the start of the trial. The vaccine had no observable effect on fat production in milk or on streptococcal infections.
Key words
References
- The problem of immunization against staphylococcal mastitis.Br. Vet. J. 1978; 134: 412
- Epi Info®, Version 6.Ctr. Dis. Control Prev., Atlanta, GA.1994
- Potential for vaccination against infections caused by Staphylococcus aureus.Vaccine. 1991; 9: 221
- Field trials of a vaccine against bovine mastitis. 1. Evaluation in heifers.J. Dairy Sci. 1997; 80: 845
- Statistics with Stata® 3.Duxbury Press, Belmont, CA.1993
- Applied Logistic Regression.John Wiley & Sons, New York, NY1989
- Vaccination programs for preventing and controlling mastitis.in: Proc. Natl. Mastitis Counc. Reg. Mtg., Syracuse, NY. Natl. Mastitis Counc., Inc., Arlington, VA1993: 64
- A field trial with an experimental vaccine against Staphylococcus aureus mastitis in cattle. 1. Clinical parameters.J. Dairy Sci. 1994; 77: 1267
- Evaluation of protein A and a commercial bacterin as vaccine against Staphylococcus aureus mastitis by experimental challenge.J. Dairy Sci. 1985; 68: 726
- Virulence factors involved in the pathogenesis of bovine intramammary infections due to Staphylococcus aureus.J. Med. Microbiol. 1994; 40: 79
- Staphylococcal mastitis vaccine.Vaccine. 1992; 10: 359
- A field trial to test the efficacy of a staphylococcal mastitis vaccine in commercial dairies in Australia.in: Proc. Int. Symp. Bovine Mastitis. Natl. Mastitis Counc. and Am. Assoc, Bovine Pract., Indianapolis, IN.1990: 73
- Staphylococcal capsular vaccine for preventing mastitis in two herds in Georgia.J. Dairy Sci. 1984; 67: 620
Article info
Publication history
Accepted:
August 23,
1996
Received:
December 27,
1995
Identification
Copyright
© 1997 American Dairy Science Association. Published by Elsevier Inc.
User license
Elsevier user license | How you can reuse
Elsevier's open access license policy

Elsevier user license
Permitted
For non-commercial purposes:
- Read, print & download
- Text & data mine
- Translate the article
Not Permitted
- Reuse portions or extracts from the article in other works
- Redistribute or republish the final article
- Sell or re-use for commercial purposes
Elsevier's open access license policy